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Crystal structure of the mercury-bound form of MerB, the Organomercurial Lyase involved in a bacterial mercury resistance system

Source organism: Escherichia coli
Biochemical function: alkylmercury lyase activity
Biological process: response to mercury ion
Cellular component: not assigned

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EC 4.99.1.2: Alkylmercury lyase

Reaction catalysed:
An alkylmercury + H(+) = an alkane + Hg(2+)
Systematic name:
Alkylmercury mercury(II)-lyase (alkane-forming)
Alternative Name(s):
  • Alkylmercury mercuric-lyase
  • Alkylmercury mercuric-lyase (alkane-forming)
  • Organomercurial lyase
  • Organomercury lyase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF03243
Domain description: Alkylmercury lyase
Occurring in:
  1. Alkylmercury lyase
The deposited structure of PDB entry 3f0p contains 2 copies of Pfam domain PF03243 (Alkylmercury lyase) in Alkylmercury lyase. Showing 1 copy in chain A.

PF12324
Domain description: Helix-turn-helix domain of alkylmercury lyase
Occurring in:
  1. Alkylmercury lyase
The deposited structure of PDB entry 3f0p contains 2 copies of Pfam domain PF12324 (Helix-turn-helix domain of alkylmercury lyase) in Alkylmercury lyase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR004927
Domain description: Alkylmercury lyase
Occurring in:
  1. Alkylmercury lyase
IPR036390
Domain description: Winged helix DNA-binding domain superfamily
Occurring in:
  1. Alkylmercury lyase
IPR024259
Domain description: Alkylmercury lyase, helix-turn-helix domain
Occurring in:
  1. Alkylmercury lyase

Structure domain

CATH CATH domain
3.30.450.410
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Beta-Lactamase
Homology: Beta-Lactamase
Occurring in:
  1. Alkylmercury lyase
The deposited structure of PDB entry 3f0p contains 2 copies of CATH domain 3.30.450.410 (Beta-Lactamase) in Alkylmercury lyase. Showing 1 copy in chain A.

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