Structure analysis

First pair of Fibronectin type III domains and part of the connecting segment of the integrin beta4

X-ray diffraction
1.75Å resolution
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 12414.04 Å2
Buried surface area: 905.06 Å2
Dissociation area: 101.09 Å2
Dissociation energy (ΔGdiss): -4.1 kcal/mol
Dissociation entropy (TΔSdiss): 1.29 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-147640
Assembly 2
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Multimeric state: monomeric
Accessible surface area: 12483.62 Å2
Buried surface area: 773.3 Å2
Dissociation area: 99.23 Å2
Dissociation energy (ΔGdiss): -2.39 kcal/mol
Dissociation entropy (TΔSdiss): -0.41 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-147640

Macromolecules

Chains: A, B
Length: 234 amino acids
Theoretical weight: 26.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P16144 (Residues: 1126-1355; Coverage: 13%)
Gene name: ITGB4
Pfam: Fibronectin type III domain
InterPro:
CATH: Immunoglobulins
PDBe-KB: UniProt Coverage View: P16144  
123420406080100120140160180200220
 
100200
UniProt
P16144
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites

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