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Crystal structure of 2,3-dimethylmalate lyase, a PEP mutase/isocitrate lyase superfamily member, triclinic crystal form

Source organism: Aspergillus niger
Biochemical function: metal ion binding
Biological process: not assigned
Cellular component: not assigned

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EC 4.1.3.30: Methylisocitrate lyase

Reaction catalysed:
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate
Systematic name:
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase (succinate-forming)
Alternative Name(s):
  • (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase
  • 2-methylisocitrate lyase
  • MICL

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF13714
Domain description: Phosphoenolpyruvate phosphomutase
Occurring in:
  1. Oxaloacetate hydrolase class protein
The deposited structure of PDB entry 3fa4 contains 12 copies of Pfam domain PF13714 (Phosphoenolpyruvate phosphomutase) in Oxaloacetate hydrolase class protein. Showing 1 copy in chain L.

InterPro InterPro annotations
IPR018523
Domain description: Isocitrate lyase/phosphorylmutase, conserved site
Occurring in:
  1. Oxaloacetate hydrolase class protein
IPR039556
Domain description: ICL/PEPM domain
Occurring in:
  1. Oxaloacetate hydrolase class protein
IPR015813
Domain description: Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily
Occurring in:
  1. Oxaloacetate hydrolase class protein
IPR040442
Domain description: Pyruvate kinase-like domain superfamily
Occurring in:
  1. Oxaloacetate hydrolase class protein

Structure domain

CATH CATH domain
3.20.20.60
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Phosphoenolpyruvate-binding domains
Occurring in:
  1. Oxaloacetate hydrolase class protein
The deposited structure of PDB entry 3fa4 contains 12 copies of CATH domain 3.20.20.60 (TIM Barrel) in Oxaloacetate hydrolase class protein. Showing 1 copy in chain B.

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