› 3fas

X-ray diffraction
1.4Å resolution

X-ray structure of iGluR4 flip ligand-binding core (S1S2) in complex with (S)-glutamate at 1.40A resolution

Released:
DOI: 10.2210/pdb3fas/pdb
PDB entry 3fas coloured by chain, front view.
PDB entry 3fas coloured by chain, side view.
PDB entry 3fas coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4.
Kasper C, Frydenvang K, Naur P, Gajhede M, Pickering DS, Kastrup JS
FEBS Lett 582 4089-94 (2008)
PMID: 19022251

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148618 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 260 amino acids
Theoretical weight: 29.02 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P19493 (Residues: 415-528, 654-796; Coverage: 29%)
  • Best match: P19493-2 (Residues: 415-528, 654-796)
Gene names: Glur4, Gria4
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

3 bound ligands:
Ligand GLU 2 x GLU
Ligand SO4 8 x SO4
Ligand GOL 9 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-2
Spacegroup: P21
Unit cell:
a: 47.425Å b: 105.231Å c: 66.538Å
α: 90° β: 97.24° γ: 90°
R-values:
R R work R free
0.167 0.167 0.183
Expression system: Escherichia coli

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Citations

3 review citations

Functional insights from glutamate receptor ion channel structures.
Kumar et al. (2013)
2 more

4 mentions without citation

Update on Omega-3 Polyunsaturated Fatty Acids on Cardiovascular Health.
Rodriguez et al. (2022)
3 more