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Structure of S. pombe Pop2p - Zn2+ and Mn2+ bound form

Source organism: Schizosaccharomyces pombe
Biochemical function: metal ion binding
Biological process: regulatory ncRNA-mediated gene silencing
Cellular component: CCR4-NOT core complex

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EC 3.1.13.4: Poly(A)-specific ribonuclease

Reaction catalysed:
Exonucleolytic cleavage of poly(A) to 5'-AMP
Alternative Name(s):
  • 2',3'-exoribonuclease
  • 3'-exoribonuclease

GO terms

Sequence family

Pfam Protein family (Pfam)
PF04857
Domain description: CAF1 family ribonuclease
Occurring in:
  1. Poly(A) ribonuclease pop2
The deposited structure of PDB entry 3g0z contains 2 copies of Pfam domain PF04857 (CAF1 family ribonuclease) in Poly(A) ribonuclease pop2. Showing 2 copies in chain A.

InterPro InterPro annotations
IPR006941
Domain description: Ribonuclease CAF1
Occurring in:
  1. Poly(A) ribonuclease pop2
IPR039637
Domain description: CCR4-NOT transcription complex subunit 7/8/Pop2
Occurring in:
  1. Poly(A) ribonuclease pop2
IPR012337
Domain description: Ribonuclease H-like superfamily
Occurring in:
  1. Poly(A) ribonuclease pop2
IPR036397
Domain description: Ribonuclease H superfamily
Occurring in:
  1. Poly(A) ribonuclease pop2

Structure domain

CATH CATH domain
3.30.420.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Nucleotidyltransferase; domain 5
Homology: Ribonuclease H-like superfamily/Ribonuclease H
Occurring in:
  1. Poly(A) ribonuclease pop2
The deposited structure of PDB entry 3g0z contains 1 copy of CATH domain 3.30.420.10 (Nucleotidyltransferase; domain 5) in Poly(A) ribonuclease pop2. Showing 1 copy in chain A.

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