› › Structure analysis

Crystal structure of human liver 5beta-reductase (AKR1D1) in complex with NADP and Finasteride. Resolution 1.70 A

X-ray diffraction
1.701Å resolution
PDB entry 3g1r coloured by chain, front view.
PDB entry 3g1r coloured by chain, side view.
PDB entry 3g1r coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Quick links

Assemblies

Assembly 1
Download    3D Visualisation
Assembly Name: Aldo-keto reductase family 1 member D1
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 13876.37 Å2
Buried surface area: 1205.69 Å2
Dissociation area: 602.85 Å2
Dissociation energy (ΔGdiss): 8.04 kcal/mol
Dissociation entropy (TΔSdiss): 6.44 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-156430
Assembly 2 (preferred)
Download    3D Visualisation
Assembly Name: Aldo-keto reductase family 1 member D1
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 13651.49 Å2
Buried surface area: 1222.21 Å2
Dissociation area: 611.1 Å2
Dissociation energy (ΔGdiss): 7.99 kcal/mol
Dissociation entropy (TΔSdiss): 6.45 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-156430

Macromolecules

Aldo-keto reductase family 1 member D1
Chains: A, B
Length: 346 amino acids
Theoretical weight: 39.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51857 (Residues: 1-326; Coverage: 100%)
Gene names: AKR1D1, SRD5B1
Pfam: Aldo/keto reductase family
InterPro:
CATH: NADP-dependent oxidoreductase domain
Aldo-keto reductase family 1 member D1 in PDB entry 3g1r, assembly 2, front view.
Aldo-keto reductase family 1 member D1 in PDB entry 3g1r, assembly 2, side view.
Aldo-keto reductase family 1 member D1 in PDB entry 3g1r, assembly 2, top view.
Molecule details ›

Search similar proteins

Quick links