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An ensemble of structures of Burkholderia pseudomallei 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase.

Figure 1
Davies DR, Staker BL, Abendroth JA, Edwards TE, Hartley R, Leonard J, Kim H, Rychel AL, Hewitt SN, Myler PJ, Stewart LJ
OpenAccess logo Acta Crystallogr Sect F Struct Biol Cryst Commun 67 1044-50 (2011)
Related entries: 3ezn, 3fdz, 3gp3, 3gw8, 3lnt

Cited: 11 times
EuropePMC logo PMID: 21904048

Abstract

Burkholderia pseudomallei is a soil-dwelling bacterium endemic to Southeast Asia and Northern Australia. Burkholderia is responsible for melioidosis, a serious infection of the skin. The enzyme 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (PGAM) catalyzes the interconversion of 3-phosphoglycerate and 2-phosphoglycerate, a key step in the glycolytic pathway. As such it is an extensively studied enzyme and X-ray crystal structures of PGAM enzymes from multiple species have been elucidated. Vanadate is a phosphate mimic that is a powerful tool for studying enzymatic mechanisms in phosphoryl-transfer enzymes such as phosphoglycerate mutase. However, to date no X-ray crystal structures of phosphoglycerate mutase have been solved with vanadate acting as a substrate mimic. Here, two vanadate complexes together with an ensemble of substrate and fragment-bound structures that provide a comprehensive picture of the function of the Burkholderia enzyme are reported.

Articles - 3gp5 mentioned but not cited (2)

  1. Structure and activity of the metal-independent fructose-1,6-bisphosphatase YK23 from Saccharomyces cerevisiae. Kuznetsova E, Xu L, Singer A, Brown G, Dong A, Flick R, Cui H, Cuff M, Joachimiak A, Savchenko A, Yakunin AF. J. Biol. Chem. 285 21049-21059 (2010)
  2. An ensemble of structures of Burkholderia pseudomallei 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase. Davies DR, Staker BL, Abendroth JA, Edwards TE, Hartley R, Leonard J, Kim H, Rychel AL, Hewitt SN, Myler PJ, Stewart LJ. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 67 1044-1050 (2011)


Articles citing this publication (9)

  1. Oxidative stress activates SIRT2 to deacetylate and stimulate phosphoglycerate mutase. Xu Y, Li F, Lv L, Li T, Zhou X, Deng CX, Guan KL, Lei QY, Xiong Y. Cancer Res. 74 3630-3642 (2014)
  2. Comparative proteomics-based identification of genes associated with glycopeptide resistance in clinically derived heterogeneous vancomycin-intermediate Staphylococcus aureus strains. Chen H, Liu Y, Zhao C, Xiao D, Zhang J, Zhang F, Chen M, Wang H. PLoS ONE 8 e66880 (2013)
  3. Mechanism of dephosphorylation of glucosyl-3-phosphoglycerate by a histidine phosphatase. Zheng Q, Jiang D, Zhang W, Zhang Q, Zhao Q, Jin J, Li X, Yang H, Bartlam M, Shaw N, Zhou W, Rao Z. J Biol Chem 289 21242-21251 (2014)
  4. Structural basis for differential recognition of phosphohistidine-containing peptides by 1-pHis and 3-pHis monoclonal antibodies. Kalagiri R, Stanfield RL, Meisenhelder J, La Clair JJ, Fuhs SR, Wilson IA, Hunter T. Proc Natl Acad Sci U S A 118 e2010644118 (2021)
  5. Effects of Sevoflurane Inhalation Anesthesia on the Intestinal Microbiome in Mice. Han C, Zhang Z, Guo N, Li X, Yang M, Peng Y, Ma X, Yu K, Wang C. Front Cell Infect Microbiol 11 633527 (2021)
  6. CSGID Solves Structures and Identifies Phenotypes for Five Enzymes in Toxoplasma gondii. Lykins JD, Filippova EV, Halavaty AS, Minasov G, Zhou Y, Dubrovska I, Flores KJ, Shuvalova LA, Ruan J, El Bissati K, Dovgin S, Roberts CW, Woods S, Moulton JD, Moulton H, McPhillie MJ, Muench SP, Fishwick CWG, Sabini E, Shanmugam D, Roos DS, McLeod R, Anderson WF, Ngô HM. Front Cell Infect Microbiol 8 352 (2018)
  7. Molecular dynamics simulation reveals how phosphorylation of tyrosine 26 of phosphoglycerate mutase 1 upregulates glycolysis and promotes tumor growth. Wang Y, Cai WS, Chen L, Wang G. Oncotarget 8 12093-12107 (2017)
  8. A putative 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase is involved in the virulence, carbohydrate metabolism, biofilm formation, twitching halo, and osmotic tolerance in Acidovorax citrulli. Lee J, Lee J, Cho Y, Choi J, Han SW. Front Plant Sci 13 1039420 (2022)
  9. Molecular Details of Actinomycin D-Treated MRSA Revealed via High-Dimensional Data. Xia X, Liu J, Huang L, Zhang X, Deng Y, Li F, Liu Z, Huang R. Mar Drugs 20 114 (2022)


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