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Crystal structure of PagP in SDS/MPD

Source organism: Escherichia coli K-12
Biochemical function: acyltransferase activity
Biological process: lipid A biosynthetic process
Cellular component: cell outer membrane

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EC 2.3.1.251: Lipid IV(A) palmitoyltransferase

Reaction catalysed:
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A = 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
Systematic name:
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine:lipid-IV(A) palmitoyltransferase
Alternative Name(s):
  • CrcA (gene name)
  • PagP

GO terms

Sequence family

Pfam Protein family (Pfam)
PF07017
Domain description: Antimicrobial peptide resistance and lipid A acylation protein PagP
Occurring in:
  1. Lipid A palmitoyltransferase PagP
The deposited structure of PDB entry 3gp6 contains 1 copy of Pfam domain PF07017 (Antimicrobial peptide resistance and lipid A acylation protein PagP) in Lipid A palmitoyltransferase PagP. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR009746
Domain description: Llipid A acylation PagP
Occurring in:
  1. Lipid A palmitoyltransferase PagP
IPR011250
Domain description: Outer membrane protein/outer membrane enzyme PagP, beta-barrel
Occurring in:
  1. Lipid A palmitoyltransferase PagP

Structure domain

CATH CATH domain
2.40.160.20
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Porin
Homology: Porin
Occurring in:
  1. Lipid A palmitoyltransferase PagP
The deposited structure of PDB entry 3gp6 contains 1 copy of CATH domain 2.40.160.20 (Porin) in Lipid A palmitoyltransferase PagP. Showing 1 copy in chain A.

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