› 3gre

X-ray diffraction
1.8Å resolution

Crystal structure of Saccharomyces cerevisiae Vps15 WD repeat domain

Released:
DOI: 10.2210/pdb3gre/pdb
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PDB entry 3gre coloured by chain, front view.
PDB entry 3gre coloured by chain, side view.
PDB entry 3gre coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Structure and function of Vps15 in the endosomal G protein signaling pathway.
Heenan EJ, Vanhooke JL, Temple BR, Betts L, Sondek JE, Dohlman HG
Biochemistry 48 6390-401 (2009)
PMID: 19445518

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149548 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase VPS15 Chain: A
Molecule details ›
Chain: A
Length: 437 amino acids
Theoretical weight: 48.95 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P22219 (Residues: 1027-1454; Coverage: 29%)
Gene names: GRD8, VAC4, VPL19, VPS15, YBR0825, YBR097W

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P3121
Unit cell:
a: 85.493Å b: 85.493Å c: 132.821Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.211 0.209 0.246
Expression system: Trichoplusia ni

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Citations

8 review citations

The emerging mechanisms of isoform-specific PI3K signalling.
Vanhaesebroeck et al. (2010)
7 more

5 mentions without citation

Recent Advances in Single-Particle Electron Microscopic Analysis of Autophagy Degradation Machinery.
Cheung et al. (2020)
4 more

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