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Human DNA polymerase iota in complex with T template DNA and incoming ddADP

Source organism: Homo sapiens
Biochemical function: DNA-directed DNA polymerase activity
Biological process: DNA repair
Cellular component: not assigned

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EC 2.7.7.7: DNA-directed DNA polymerase

Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Systematic name:
Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
Alternative Name(s):
  • DNA duplicase
  • DNA nucleotidyltransferase
  • DNA nucleotidyltransferase (DNA-directed)
  • DNA polymerase
  • DNA polymerase I
  • DNA polymerase II
  • DNA polymerase III
  • DNA polymerase alpha
  • DNA polymerase beta
  • DNA polymerase gamma
  • DNA replicase
  • DNA-dependent DNA polymerase
  • Deoxynucleate polymerase
  • Deoxyribonucleate nucleotidyltransferase
  • Deoxyribonucleic acid duplicase
  • Deoxyribonucleic acid polymerase
  • Deoxyribonucleic duplicase
  • Deoxyribonucleic polymerase
  • Deoxyribonucleic polymerase I
  • Duplicase
  • Klenow fragment
  • Sequenase
  • Taq DNA polymerase
  • Taq Pol I
  • Tca DNA polymerase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF11799
Domain description: impB/mucB/samB family C-terminal domain
Occurring in:
  1. DNA polymerase iota
The deposited structure of PDB entry 3gv5 contains 2 copies of Pfam domain PF11799 (impB/mucB/samB family C-terminal domain) in DNA polymerase iota. Showing 1 copy in chain D.

PF21999
Domain description: DNA polymerase-iota, thumb domain
Occurring in:
  1. DNA polymerase iota

PF00817
Domain description: impB/mucB/samB family
Occurring in:
  1. DNA polymerase iota
The deposited structure of PDB entry 3gv5 contains 2 copies of Pfam domain PF00817 (impB/mucB/samB family) in DNA polymerase iota. Showing 1 copy in chain D.

InterPro InterPro annotations
IPR036775
Domain description: DNA polymerase, Y-family, little finger domain superfamily
Occurring in:
  1. DNA polymerase iota
IPR001126
Domain description: UmuC domain
Occurring in:
  1. DNA polymerase iota
IPR017961
Domain description: DNA polymerase, Y-family, little finger domain
Occurring in:
  1. DNA polymerase iota
IPR043128
Domain description: Reverse transcriptase/Diguanylate cyclase domain
Occurring in:
  1. DNA polymerase iota
IPR043502
Domain description: DNA/RNA polymerase superfamily
Occurring in:
  1. DNA polymerase iota

Structure domains

CATH CATH domains
3.30.70.270
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Alpha-Beta Plaits
Occurring in:
  1. DNA polymerase iota
The deposited structure of PDB entry 3gv5 contains 2 copies of CATH domain 3.30.70.270 (Alpha-Beta Plaits) in DNA polymerase iota. Showing 1 copy in chain D.
3.30.1490.100
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Dna Ligase; domain 1
Homology: DNA polymerase, Y-family, little finger domain
Occurring in:
  1. DNA polymerase iota
The deposited structure of PDB entry 3gv5 contains 2 copies of CATH domain 3.30.1490.100 (Dna Ligase; domain 1) in DNA polymerase iota. Showing 1 copy in chain D.
1.10.150.20
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: DNA polymerase; domain 1
Homology: 5' to 3' exonuclease, C-terminal subdomain
Occurring in:
  1. DNA polymerase iota
The deposited structure of PDB entry 3gv5 contains 2 copies of CATH domain 1.10.150.20 (DNA polymerase; domain 1) in DNA polymerase iota. Showing 1 copy in chain D.
3.40.1170.60
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: MutS, DNA mismatch repair protein, domain I
Homology: MutS, DNA mismatch repair protein, domain I
Occurring in:
  1. DNA polymerase iota
The deposited structure of PDB entry 3gv5 contains 2 copies of CATH domain 3.40.1170.60 (MutS, DNA mismatch repair protein, domain I) in DNA polymerase iota. Showing 1 copy in chain D.

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