› 3gvu

X-ray diffraction
2.05Å resolution

The crystal structure of human ABL2 in complex with GLEEVEC

Released:
DOI: 10.2210/pdb3gvu/pdb
PDB entry 3gvu coloured by chain, front view.
PDB entry 3gvu coloured by chain, side view.
PDB entry 3gvu coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Ugochukwu E, Salah E, Barr A, Mahajan P, Shrestha B, Savitsky P, Chaikuad A, Filippakopoulos P, Roos A, Pike ACW, von Delft F, Bountra C, Arrowsmith CH, Weigelt J, Edwards A, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-545206 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ABL2 Chain: A
Molecule details ›
Chain: A
Length: 292 amino acids
Theoretical weight: 33.54 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P42684 (Residues: 279-546; Coverage: 23%)
Gene names: ABL2, ABLL, ARG
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand STI 2 x STI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2221
Unit cell:
a: 88.46Å b: 99.44Å c: 87.81Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.189 0.226
Expression system: Trichoplusia ni

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