› › Function and Biology

Crystal structure of the Ribonuclease H1 from Chlorobium tepidum

Source organism: Chlorobaculum tepidum
Biochemical function: metal ion binding
Biological process: DNA replication, removal of RNA primer
Cellular component: cytoplasm

Quick links

EC 3.1.26.4: Ribonuclease H

Reaction catalysed:
Endonucleolytic cleavage to 5'-phosphomonoester.
Systematic name:
-
Alternative Name(s):
  • Calf thymus ribonuclease H
  • Endoribonuclease H
  • Endoribonuclease H (calf thymus)
  • Hybrid nuclease
  • Hybrid ribonuclease
  • Hybridase
  • Hybridase (ribonuclease H)
  • RNA*DNA hybrid ribonucleotidohydrolase
  • RNase H

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00075
Domain description: RNase H
Occurring in:
  1. Ribonuclease H
The deposited structure of PDB entry 3h08 contains 2 copies of Pfam domain PF00075 (RNase H) in Ribonuclease H. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR022892
Domain description: Ribonuclease HI
Occurring in:
  1. Ribonuclease H
IPR002156
Domain description: Ribonuclease H domain
Occurring in:
  1. Ribonuclease H
IPR012337
Domain description: Ribonuclease H-like superfamily
Occurring in:
  1. Ribonuclease H
IPR036397
Domain description: Ribonuclease H superfamily
Occurring in:
  1. Ribonuclease H

Structure domain

CATH CATH domain
3.30.420.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Nucleotidyltransferase; domain 5
Homology: Ribonuclease H-like superfamily/Ribonuclease H
Occurring in:
  1. Ribonuclease H
The deposited structure of PDB entry 3h08 contains 2 copies of CATH domain 3.30.420.10 (Nucleotidyltransferase; domain 5) in Ribonuclease H. Showing 1 copy in chain B.

Quick links