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Structure of the C-terminal domain (MsrB) of Neisseria meningitidis PilB (complex with substrate)

Source organism: Neisseria meningitidis serogroup A
Biochemical function: peptide-methionine (R)-S-oxide reductase activity
Biological process: protein repair
Cellular component: not assigned

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EC 1.8.4.11: Peptide-methionine (S)-S-oxide reductase

Reaction catalysed:
L-methionine + thioredoxin disulfide + H(2)O = L-methionine (S)-S-oxide + thioredoxin
Systematic name:
Peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase (L-methionine (S)-S-oxide-forming)
Alternative Name(s):
  • Methionine S-oxide reductase
  • Methionine S-oxide reductase (S-form oxidizing)
  • Methionine sulfoxide reductase
  • Methionine sulfoxide reductase A
  • Methionine sulphoxide reductase A
  • MsrA
  • Peptide Met(O) reductase
  • Peptide methionine sulfoxide reductase

EC 1.8.4.12: Peptide-methionine (R)-S-oxide reductase

Reaction catalysed:
Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (R)-S-oxide + thioredoxin
Systematic name:
Peptide-methionine:thioredoxin-disulfide S-oxidoreductase (methionine (R)-S-oxide-forming)
Alternative Name(s):
  • Methionine S-oxide reductase
  • Methionine S-oxide reductase (R-form oxidizing)
  • Methionine sulfoxide reductase
  • Methionine sulfoxide reductase B
  • MsrB
  • PMRsr
  • PMSR
  • PilB
  • SelR
  • SelX
  • Selenoprotein R

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01641
Domain description: SelR domain
Occurring in:
  1. Peptide methionine sulfoxide reductase MsrA/MsrB
The deposited structure of PDB entry 3hch contains 2 copies of Pfam domain PF01641 (SelR domain) in Peptide methionine sulfoxide reductase MsrA/MsrB. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002579
Domain description: Peptide methionine sulphoxide reductase MrsB domain
Occurring in:
  1. Peptide methionine sulfoxide reductase MsrA/MsrB
IPR028427
Domain description: Peptide methionine sulfoxide reductase MsrB
Occurring in:
  1. Peptide methionine sulfoxide reductase MsrA/MsrB
IPR011057
Domain description: Mss4-like superfamily
Occurring in:
  1. Peptide methionine sulfoxide reductase MsrA/MsrB

Structure domain

CATH CATH domain
2.170.150.20
Class: Mainly Beta
Architecture: Beta Complex
Topology: Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A
Homology: Peptide methionine sulfoxide reductase.
Occurring in:
  1. Peptide methionine sulfoxide reductase MsrA/MsrB
The deposited structure of PDB entry 3hch contains 2 copies of CATH domain 2.170.150.20 (Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A) in Peptide methionine sulfoxide reductase MsrA/MsrB. Showing 1 copy in chain A.

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