› 3hdn

X-ray diffraction
3.1Å resolution

Crystal structure of serum and glucocorticoid-regulated kinase 1 in complex with compound 2

Released:
DOI: 10.2210/pdb3hdn/pdb
PDB entry 3hdn coloured by chain, front view.
PDB entry 3hdn coloured by chain, side view.
PDB entry 3hdn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Design and synthesis of orally bioavailable serum and glucocorticoid-regulated kinase 1 (SGK1) inhibitors.
Hammond M, Washburn DG, Hoang HT, Manns S, Frazee JS, Nakamura H, Patterson JR, Trizna W, Wu C, Azzarano LM, Nagilla R, Nord M, Trejo R, Head MS, Zhao B, Smallwood AM, Hightower K, Laping NJ, Schnackenberg CG, Thompson SK
Bioorg Med Chem Lett 19 4441-5 (2009)
PMID: 19497745

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126120 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase Sgk1 Chain: A
Molecule details ›
Chain: A
Length: 373 amino acids
Theoretical weight: 42.3 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: O00141 (Residues: 60-431; Coverage: 86%)
Gene names: SGK, SGK1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand GMG 1 x GMG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P6522
Unit cell:
a: 96.812Å b: 96.812Å c: 150.779Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.251 0.25 0.278
Expression system: unidentified baculovirus

Quick links

Citations

1 review citation

Therapeutic potential of serum and glucocorticoid inducible kinase inhibition.
Lang et al. (2013)
12 other articles

8 mentions without citation

The azaindole framework in the design of kinase inhibitors.
Mérour et al. (2014)
7 more