EC 1.4.3.22: Diamine oxidase
Reaction catalysed:
Histamine + H(2)O + O(2) = (imidazol-4-yl)acetaldehyde + NH(3) + H(2)O(2)
Systematic name:
Histamine:oxygen oxidoreductase (deaminating)
Alternative Name(s):
- Amine oxidase
- Amine oxidase (copper-containing)
- CAO
- Copper amine oxidase
- Cu-containing amine oxidase
- Diamino oxhydrase
- Histaminase
- Histamine deaminase
- SSAO
- Semicarbazide-sensitive amine oxidase
GO terms
Biochemical function:
- histamine oxidase activity
- diamine oxidase activity
- putrescine oxidase activity
- quinone binding
- metal ion binding
- protein homodimerization activity
- oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
- oxidoreductase activity
- heparin binding
- primary methylamine oxidase activity
- protein binding
- calcium ion binding
- copper ion binding
Biological process:
Cellular component:
Sequence families
Protein families (Pfam)
![The deposited structure of PDB entry 3hig contains 2 copies of Pfam domain PF01179 (Copper amine oxidase, enzyme domain) in Amiloride-sensitive amine oxidase [copper-containing]. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/3hig_1_A_Pfam_PF01179_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>3hig</span> contains 2 copies of Pfam domain <span class='highlight'>PF01179 (Copper amine oxidase, enzyme domain)</span> in <span class='highlight'>Amiloride-sensitive amine oxidase [copper-containing]</span>. Showing 1 copy in chain <span class='highlight'>A</span>.")
![The deposited structure of PDB entry 3hig contains 2 copies of Pfam domain PF02728 (Copper amine oxidase, N3 domain) in Amiloride-sensitive amine oxidase [copper-containing]. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/3hig_1_A_Pfam_PF02728_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>3hig</span> contains 2 copies of Pfam domain <span class='highlight'>PF02728 (Copper amine oxidase, N3 domain)</span> in <span class='highlight'>Amiloride-sensitive amine oxidase [copper-containing]</span>. Showing 1 copy in chain <span class='highlight'>A</span>.")
![The deposited structure of PDB entry 3hig contains 2 copies of Pfam domain PF02727 (Copper amine oxidase, N2 domain) in Amiloride-sensitive amine oxidase [copper-containing]. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/3hig_1_A_Pfam_PF02727_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>3hig</span> contains 2 copies of Pfam domain <span class='highlight'>PF02727 (Copper amine oxidase, N2 domain)</span> in <span class='highlight'>Amiloride-sensitive amine oxidase [copper-containing]</span>. Showing 1 copy in chain <span class='highlight'>A</span>.")
InterPro annotations
Structure domains
CATH domains
3.10.450.40
Class:
Alpha Beta
Architecture:
Roll
Topology:
Nuclear Transport Factor 2; Chain: A,
Homology:
Nuclear Transport Factor 2; Chain: A,
Occurring in:
![The deposited structure of PDB entry 3hig contains 4 copies of CATH domain 3.10.450.40 (Nuclear Transport Factor 2; Chain: A,) in Amiloride-sensitive amine oxidase [copper-containing]. Showing 2 copies in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/3hig_1_A_CATH_3.10.450.40_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>3hig</span> contains 4 copies of CATH domain <span class='highlight'>3.10.450.40 (Nuclear Transport Factor 2; Chain: A,)</span> in <span class='highlight'>Amiloride-sensitive amine oxidase [copper-containing]</span>. Showing 2 copies in chain <span class='highlight'>A</span>.")
![The deposited structure of PDB entry 3hig contains 2 copies of CATH domain 2.70.98.20 (Beta-galactosidase; Chain A, domain 5) in Amiloride-sensitive amine oxidase [copper-containing]. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/3hig_1_A_CATH_2.70.98.20_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>3hig</span> contains 2 copies of CATH domain <span class='highlight'>2.70.98.20 (Beta-galactosidase; Chain A, domain 5)</span> in <span class='highlight'>Amiloride-sensitive amine oxidase [copper-containing]</span>. Showing 1 copy in chain <span class='highlight'>A</span>.")