› 3hk1

X-ray diffraction
1.7Å resolution

Identification and Characterization of a Small Molecule Inhibitor of Fatty Acid Binding Proteins

Released:
DOI: 10.2210/pdb3hk1/pdb
PDB entry 3hk1 coloured by chain, front view.
PDB entry 3hk1 coloured by chain, side view.
PDB entry 3hk1 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins.
Hertzel AV, Hellberg K, Reynolds JM, Kruse AC, Juhlmann BE, Smith AJ, Sanders MA, Ohlendorf DH, Suttles J, Bernlohr DA
J Med Chem 52 6024-31 (2009)
PMID: 19754198

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137403 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fatty acid-binding protein, adipocyte Chain: A
Molecule details ›
Chain: A
Length: 131 amino acids
Theoretical weight: 14.54 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P04117 (Residues: 2-132; Coverage: 99%)
Gene names: Ap2, Fabp4
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

1 bound ligand:
Ligand B64 1 x B64
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: C2221
Unit cell:
a: 77.017Å b: 94.113Å c: 49.662Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.176 0.175 0.195
Expression system: Escherichia coli

Quick links

Citations

14 review citations

Fatty Acid-Binding Protein 4 (FABP4): Pathophysiological Insights and Potent Clinical Biomarker of Metabolic and Cardiovascular Diseases.
Furuhashi et al. (2014)
13 more

4 mentions without citation

Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins.
Hertzel et al. (2009)
3 more