Function and Biology

Crystal structure of Toxoplasma gondii CDPK3, TGME49_105860

Source organism: Toxoplasma gondii ME49
Biochemical function: ATP binding
Biological process: protein phosphorylation
Cellular component: not assigned

EC 2.7.11.17: Ca(2+)/calmodulin-dependent protein kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (Ca(2+)/calmodulin-dependent)
Alternative Name(s):
  • ATP:caldesmon O-phosphotransferase
  • CAM PKII
  • Ca(2+)/calmodulin-dependent microtubule-associated protein 2 kinase
  • Ca(2+)/calmodulin-dependent protein kinase 1
  • Ca(2+)/calmodulin-dependent protein kinase II
  • Ca(2+)/calmodulin-dependent protein kinase IV
  • Ca(2+)/calmodulin-dependent protein kinase kinase
  • Ca(2+)/calmodulin-dependent protein kinase kinase beta
  • CaM kinase
  • CaM kinase II
  • CaM-regulated serine/threonine kinase
  • CaMKI
  • CaMKII
  • CaMKIV
  • CaMKK-alpha
  • CaMKK-beta
  • Calcium/calmodulin-dependent protein kinase type II
  • Caldesmon kinase
  • Caldesmon kinase (phosphorylating)
  • Calmodulin-dependent kinase II
  • Microtubule-associated protein 2 kinase
  • STK20

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF13499
Domain description: EF-hand domain pair
Occurring in:
  1. Calcium-dependent protein kinase CDPK3
The deposited structure of PDB entry 3hzt contains 2 copies of Pfam domain PF13499 (EF-hand domain pair) in Calmodulin-like domain protein kinase isoform 3. Showing 2 copies in chain A.

PF00069
Domain description: Protein kinase domain
Occurring in:
  1. Calcium-dependent protein kinase CDPK3
The deposited structure of PDB entry 3hzt contains 1 copy of Pfam domain PF00069 (Protein kinase domain) in Calmodulin-like domain protein kinase isoform 3. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002048
Domain description: EF-hand domain
Occurring in:
  1. Calcium-dependent protein kinase CDPK3
IPR018247
Domain description: EF-Hand 1, calcium-binding site
Occurring in:
  1. Calcium-dependent protein kinase CDPK3
IPR011992
Domain description: EF-hand domain pair
Occurring in:
  1. Calcium-dependent protein kinase CDPK3
IPR008271
Domain description: Serine/threonine-protein kinase, active site
Occurring in:
  1. Calcium-dependent protein kinase CDPK3
IPR017441
Domain description: Protein kinase, ATP binding site
Occurring in:
  1. Calcium-dependent protein kinase CDPK3
IPR000719
Domain description: Protein kinase domain
Occurring in:
  1. Calcium-dependent protein kinase CDPK3
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Calcium-dependent protein kinase CDPK3

Structure domains

CATH CATH domains
1.10.510.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Transferase(Phosphotransferase); domain 1
Homology: Transferase(Phosphotransferase) domain 1
Occurring in:
  1. Calcium-dependent protein kinase CDPK3
The deposited structure of PDB entry 3hzt contains 1 copy of CATH domain 1.10.510.10 (Transferase(Phosphotransferase); domain 1) in Calmodulin-like domain protein kinase isoform 3. Showing 1 copy in chain A.
3.30.200.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Phosphorylase Kinase; domain 1
Homology: Phosphorylase Kinase; domain 1
Occurring in:
  1. Calcium-dependent protein kinase CDPK3
The deposited structure of PDB entry 3hzt contains 1 copy of CATH domain 3.30.200.20 (Phosphorylase Kinase; domain 1) in Calmodulin-like domain protein kinase isoform 3. Showing 1 copy in chain A.