Function and Biology

High pressure structure of I106A variant of RNase A (0.48 GPa)

Source organism: Bos taurus
Biochemical function: lyase activity
Biological process: defense response to Gram-positive bacterium
Cellular component: extracellular region

EC 4.6.1.18: Pancreatic ribonuclease

Reaction catalysed:
(1a) an (RNA) containing cytidine = an (RNA)-3'-cytidine-2',3'-cyclophosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA)
Systematic name:
RNA lyase ((RNA)-3'-cytidine/uridine-3'-phosphate and 5'-hydroxy-ribonucleotide-3'-(RNA) producing)
Alternative Name(s):
  • Alkaline ribonuclease
  • Ceratitis capitata alkaline ribonuclease
  • Endoribonuclease I
  • Gene S glycoproteins
  • Gene S locus-specific glycoproteins
  • Pancreatic RNase
  • RNase
  • RNase A
  • RNase I
  • Ribonuclease
  • Ribonuclease I
  • Ribonucleate 3'-pyrimidino-oligonucleotidohydrolase
  • Ribonucleic phosphatase
  • S-genotype-asssocd. glycoproteins
  • SLSG glycoproteins

Sequence family

Pfam Protein family (Pfam)
PF00074
Domain description: Pancreatic ribonuclease
Occurring in:
  1. Ribonuclease pancreatic
The deposited structure of PDB entry 3i7y contains 1 copy of Pfam domain PF00074 (Pancreatic ribonuclease) in Ribonuclease pancreatic. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001427
Domain description: Pancreatic ribonuclease
Occurring in:
  1. Ribonuclease pancreatic
IPR036816
Domain description: Ribonuclease A-like domain superfamily
Occurring in:
  1. Ribonuclease pancreatic
IPR023412
Domain description: Ribonuclease A-domain
Occurring in:
  1. Ribonuclease pancreatic
IPR023411
Domain description: Ribonuclease A, active site
Occurring in:
  1. Ribonuclease pancreatic

Structure domain

CATH CATH domain
3.10.130.10
Class: Alpha Beta
Architecture: Roll
Topology: P-30 Protein
Homology: Ribonuclease A-like domain
Occurring in:
  1. Ribonuclease pancreatic
The deposited structure of PDB entry 3i7y contains 1 copy of CATH domain 3.10.130.10 (P-30 Protein) in Ribonuclease pancreatic. Showing 1 copy in chain A.