› 3ico

X-ray diffraction
2.15Å resolution

Function and Biology Details

Reaction catalysed: 
6-phospho-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162092 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
6-phosphogluconolactonase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 268 amino acids
Theoretical weight: 28.12 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WQP5 (Residues: 1-247; Coverage: 100%)
Gene names: MTCY493.09, Rv1445c, devB, pgl
Sequence domains: Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
Structure domains: Rossmann fold

Ligands and Environments

1 bound ligand:
Ligand SO4 6 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P1
Unit cell:
a: 57.301Å b: 68.081Å c: 73.542Å
α: 108.5° β: 107.11° γ: 104.95°
R-values:
R R work R free
0.184 0.182 0.223
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Pleiotropic Functions of Tumor Suppressor WWOX in Normal and Cancer Cells.
Abu-Remaileh et al. (2015)
5 more