› 3ijc

X-ray diffraction
1.95Å resolution

Crystal structure of Eed in complex with NDSB-195

Released:
DOI: 10.2210/pdb3ijc/pdb
PDB entry 3ijc coloured by chain, front view.
PDB entry 3ijc coloured by chain, side view.
PDB entry 3ijc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Role of the polycomb protein EED in the propagation of repressive histone marks.
Margueron R, Justin N, Ohno K, Sharpe ML, Son J, Drury WJ, Voigt P, Martin SR, Taylor WR, De Marco V, Pirrotta V, Reinberg D, Gamblin SJ
Nature 461 762-7 (2009)
PMID: 19767730

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131010 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polycomb protein EED Chain: A
Molecule details ›
Chain: A
Length: 365 amino acids
Theoretical weight: 42.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75530 (Residues: 77-441; Coverage: 83%)
Gene name: EED
Sequence domains: WD domain, G-beta repeat
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase

Ligands and Environments

1 bound ligand:
Ligand NDS 1 x NDS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX10.1
Spacegroup: P212121
Unit cell:
a: 57.803Å b: 85.337Å c: 91.231Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.195 0.232
Expression system: Escherichia coli

Quick links

Citations

299 review citations

Histone methylation: a dynamic mark in health, disease and inheritance.
Greer et al. (2012)
298 more

1 mention without citation

Role of the polycomb protein EED in the propagation of repressive histone marks.
Margueron et al. (2009)