Function and Biology

Structural dynamics of the MecA-ClpC complex revealed by cryo-EM

Source organism: Bacillus subtilis subsp. subtilis str. 168
Biochemical function: protein binding
Biological process: establishment of competence for transformation
Cellular component: not assigned

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF02861
Domain description: Clp amino terminal domain, pathogenicity island component
Occurring in:
  1. Negative regulator of genetic competence ClpC/MecB
The deposited structure of PDB entry 3j3r contains 12 copies of Pfam domain PF02861 (Clp amino terminal domain, pathogenicity island component) in Negative regulator of genetic competence ClpC/MecB. Showing 2 copies in chain G [auth A].

PF10431
Domain description: C-terminal, D2-small domain, of ClpB protein
Occurring in:
  1. Negative regulator of genetic competence ClpC/MecB
The deposited structure of PDB entry 3j3r contains 6 copies of Pfam domain PF10431 (C-terminal, D2-small domain, of ClpB protein ) in Negative regulator of genetic competence ClpC/MecB. Showing 1 copy in chain G [auth A].

PF07724
Domain description: AAA domain (Cdc48 subfamily)
Occurring in:
  1. Negative regulator of genetic competence ClpC/MecB
The deposited structure of PDB entry 3j3r contains 6 copies of Pfam domain PF07724 (AAA domain (Cdc48 subfamily)) in Negative regulator of genetic competence ClpC/MecB. Showing 1 copy in chain G [auth A].

PF17871
Domain description: AAA lid domain
Occurring in:
  1. Negative regulator of genetic competence ClpC/MecB
The deposited structure of PDB entry 3j3r contains 6 copies of Pfam domain PF17871 (AAA lid domain) in Negative regulator of genetic competence ClpC/MecB. Showing 1 copy in chain G [auth A].

PF00004
Domain description: ATPase family associated with various cellular activities (AAA)
Occurring in:
  1. Negative regulator of genetic competence ClpC/MecB
The deposited structure of PDB entry 3j3r contains 6 copies of Pfam domain PF00004 (ATPase family associated with various cellular activities (AAA)) in Negative regulator of genetic competence ClpC/MecB. Showing 1 copy in chain G [auth A].

PF05389
Domain description: Negative regulator of genetic competence (MecA)
Occurring in:
  1. Adapter protein MecA 1
The deposited structure of PDB entry 3j3r contains 6 copies of Pfam domain PF05389 (Negative regulator of genetic competence (MecA)) in Adapter protein MecA 1. Showing 1 copy in chain A [auth 1].

InterPro InterPro annotations
IPR001270
Domain description: ClpA/B family
Occurring in:
  1. Negative regulator of genetic competence ClpC/MecB
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Negative regulator of genetic competence ClpC/MecB
IPR008681
Domain description: Negative regulator of genetic competence, MecA
Occurring in:
  1. Adapter protein MecA 1
IPR004176
Domain description: Clp, repeat (R) domain
Occurring in:
  1. Negative regulator of genetic competence ClpC/MecB
IPR019489
Domain description: Clp ATPase, C-terminal
Occurring in:
  1. Negative regulator of genetic competence ClpC/MecB
IPR003959
Domain description: ATPase, AAA-type, core
Occurring in:
  1. Negative regulator of genetic competence ClpC/MecB
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. Negative regulator of genetic competence ClpC/MecB
IPR036628
Domain description: Clp, N-terminal domain superfamily
Occurring in:
  1. Negative regulator of genetic competence ClpC/MecB
IPR028299
Domain description: ClpA/B, conserved site 2
Occurring in:
  1. Negative regulator of genetic competence ClpC/MecB
IPR001943
Domain description: UVR domain
Occurring in:
  1. Negative regulator of genetic competence ClpC/MecB
IPR041546
Domain description: ClpA/ClpB, AAA lid domain
Occurring in:
  1. Negative regulator of genetic competence ClpC/MecB
IPR018368
Domain description: ClpA/B, conserved site 1
Occurring in:
  1. Negative regulator of genetic competence ClpC/MecB
IPR038471
Domain description: MecA, C-terminal domain superfamily
Occurring in:
  1. Adapter protein MecA 1