3j6u

Electron Microscopy
9Å resolution

Cryo-EM structure of Dengue virus serotype 3 in complex with human antibody 5J7 Fab

Released:

Function and Biology Details

Reactions catalysed:
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero 480-mer (preferred)
PDBe Complex ID:
PDB-CPX-207631 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
envelope protein Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 493 amino acids
Theoretical weight: 53.68 KDa
Source organism: dengue virus type 3
Expression system: Aedes albopictus
UniProt:
  • Canonical: A9LID6 (Residues: 281-773; Coverage: 15%)
Sequence domains:
membrane protein Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 75 amino acids
Theoretical weight: 8.35 KDa
Source organism: dengue virus type 3
Expression system: Aedes albopictus
UniProt:
  • Canonical: A9LID6 (Residues: 206-280; Coverage: 2%)
Sequence domains: Flavivirus envelope glycoprotein M
Fab 5J7 heavy chain Chain: H
Fab 5J7 light chain Chain: L

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution:
Relevant EMDB volumes: EMD-5935
Expression systems:
  • Aedes albopictus
  • Not provided