› 3j7r

Electron Microscopy
3.9Å resolution

Structure of the translating mammalian ribosome-Sec61 complex

Released:
DOI: 10.2210/pdb3j7r/pdb
PDB entry 3j7r coloured by chain, front view.
PDB entry 3j7r coloured by chain, side view.
PDB entry 3j7r coloured by chain, top view.
Source organism: Sus scrofa
Primary publication:
Structure of the mammalian ribosome-Sec61 complex to 3.4 Å resolution.
Voorhees RM, Fernández IS, Scheres SH, Hegde RS
OpenAccess logo Cell 157 1632-43 (2014)
PMID: 24930395
Related structures: EMD-2644

Function and Biology Details

Reaction catalysed: 
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 86-mer (preferred)
PDBe Complex ID:
PDB-CPX-236683 (preferred)
Entry contents:
79 distinct polypeptide molecules
7 distinct RNA molecules
Macromolecules (86 distinct):
Ribosomal protein uL2 Chain: A
Molecule details ›
Chain: A
Length: 257 amino acids
Theoretical weight: 28.09 KDa
Source organism: Sus scrofa
Ribosomal protein uL3 Chain: B
Molecule details ›
Chain: B
Length: 394 amino acids
Theoretical weight: 44.76 KDa
Source organism: Sus scrofa
Large ribosomal subunit protein uL4 Chain: C
Molecule details ›
Chain: C
Length: 367 amino acids
Theoretical weight: 41.64 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1SJJ5 (Residues: 2-353, 354-365; Coverage: 85%)
Gene name: RPL4
Sequence domains:
Large ribosomal subunit protein uL18 Chain: D
Molecule details ›
Chain: D
Length: 297 amino acids
Theoretical weight: 34.42 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A287ASD0 (Residues: 1-297; Coverage: 100%)
Gene name: RPL5
Sequence domains:
Large ribosomal subunit protein eL6 Chain: E
Molecule details ›
Chain: E
Length: 236 amino acids
Theoretical weight: 27.05 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q2YGT9 (Residues: 38-284; Coverage: 83%)
Gene name: RPL6
Sequence domains:
Ribosomal protein uL30 Chain: F
Molecule details ›
Chain: F
Length: 225 amino acids
Theoretical weight: 26.59 KDa
Source organism: Sus scrofa
60S ribosomal protein L7a Chain: G
Molecule details ›
Chain: G
Length: 266 amino acids
Theoretical weight: 30.17 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1W808 (Residues: 35-300; Coverage: 89%)
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Large ribosomal subunit protein uL6 Chain: H
Molecule details ›
Chain: H
Length: 192 amino acids
Theoretical weight: 21.9 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: I3LP78 (Residues: 1-192; Coverage: 100%)
Gene name: RPL9
Sequence domains: Ribosomal protein L6
Large ribosomal subunit protein uL16 Chain: I
Molecule details ›
Chain: I
Length: 213 amino acids
Theoretical weight: 24.47 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q29195 (Residues: 2-214; Coverage: 100%)
Gene names: QM, RPL10
Sequence domains: Ribosomal protein L16p/L10e
Large ribosomal subunit protein uL5 Chain: J
Molecule details ›
Chain: J
Length: 178 amino acids
Theoretical weight: 20.25 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q29205 (Residues: 1-178; Coverage: 100%)
Gene name: RPL11
Sequence domains:
60S ribosomal protein L13 Chain: L
Molecule details ›
Chain: L
Length: 211 amino acids
Theoretical weight: 24.37 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1TBV3 (Residues: 218-428; Coverage: 49%)
Gene name: RPL13
Sequence domains: Ribosomal protein L13e
Large ribosomal subunit protein eL14 Chain: M
Molecule details ›
Chain: M
Length: 213 amino acids
Theoretical weight: 23.38 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A1XQU3 (Residues: 1-213; Coverage: 100%)
Gene name: RPL14
Sequence domains: Ribosomal protein L14
Ribosomal protein L15 Chain: N
Molecule details ›
Chain: N
Length: 204 amino acids
Theoretical weight: 24.21 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A286ZL65 (Residues: 1-204; Coverage: 100%)
Gene name: RPL15
Sequence domains: Ribosomal L15
Ribosomal protein uL13 Chain: O
Molecule details ›
Chain: O
Length: 201 amino acids
Theoretical weight: 23.44 KDa
Source organism: Sus scrofa
Large ribosomal subunit protein uL22 Chain: P
Molecule details ›
Chain: P
Length: 153 amino acids
Theoretical weight: 17.76 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A287B386 (Residues: 2-154; Coverage: 82%)
Gene name: RPL17
Sequence domains: Ribosomal protein L22p/L17e
Large ribosomal subunit protein uL15/eL18 domain-containing protein Chain: Q
Molecule details ›
Chain: Q
Length: 188 amino acids
Theoretical weight: 21.59 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1W0N5 (Residues: 1-188; Coverage: 100%)
Gene name: RPL18
Sequence domains: Ribosomal protein 60S L18 and 50S L18e
Ribosomal protein eL19 Chain: R
Molecule details ›
Chain: R
Length: 196 amino acids
Theoretical weight: 23.57 KDa
Source organism: Sus scrofa
Large ribosomal subunit protein eL20 Chain: S
Molecule details ›
Chain: S
Length: 224 amino acids
Theoretical weight: 26.1 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A287APR1 (Residues: 1-224; Coverage: 100%)
Gene name: RPL18A
Sequence domains: Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A
Large ribosomal subunit protein eL21 Chain: T
Molecule details ›
Chain: T
Length: 160 amino acids
Theoretical weight: 18.61 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P49666 (Residues: 1-160; Coverage: 100%)
Gene name: RPL21
Sequence domains: Ribosomal protein L21e
Large ribosomal subunit protein eL22 Chain: U
Molecule details ›
Chain: U
Length: 128 amino acids
Theoretical weight: 14.78 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P67985 (Residues: 1-128; Coverage: 100%)
Gene name: RPL22
Sequence domains: Ribosomal L22e protein family
Ribosomal protein uL14 Chain: V
Molecule details ›
Chain: V
Length: 140 amino acids
Theoretical weight: 14.89 KDa
Source organism: Sus scrofa
Large ribosomal subunit protein eL24 Chain: W
Molecule details ›
Chain: W
Length: 157 amino acids
Theoretical weight: 17.83 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1SH42 (Residues: 1-157; Coverage: 100%)
Gene name: RPL24
Sequence domains: Ribosomal protein L24e
Ribosomal protein uL23 Chain: X
Molecule details ›
Chain: X
Length: 156 amino acids
Theoretical weight: 17.74 KDa
Source organism: Sus scrofa
Large ribosomal subunit protein uL24 Chain: Y
Molecule details ›
Chain: Y
Length: 145 amino acids
Theoretical weight: 17.3 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1V977 (Residues: 1-145; Coverage: 100%)
Gene name: RPL26
Sequence domains:
Large ribosomal subunit protein eL27 Chain: Z
Molecule details ›
Chain: Z
Length: 136 amino acids
Theoretical weight: 15.84 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A1XQU5 (Residues: 1-136; Coverage: 100%)
Gene name: RPL27
Sequence domains:
Large ribosomal subunit protein uL15 Chain: a
Molecule details ›
Chain: a
Length: 148 amino acids
Theoretical weight: 16.63 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1SN08 (Residues: 116-263; Coverage: 56%)
Sequence domains: Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
Large ribosomal subunit protein eL29 Chain: b
Molecule details ›
Chain: b
Length: 160 amino acids
Theoretical weight: 17.55 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q95281 (Residues: 1-160; Coverage: 100%)
Gene name: RPL29
Sequence domains: Ribosomal L29e protein family
Large ribosomal subunit protein eL30 Chain: c
Molecule details ›
Chain: c
Length: 115 amino acids
Theoretical weight: 12.81 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1TXJ8 (Residues: 1-115; Coverage: 100%)
Gene name: RPL30
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Large ribosomal subunit protein eL31 Chain: d
Molecule details ›
Chain: d
Length: 125 amino acids
Theoretical weight: 14.49 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P62901 (Residues: 1-125; Coverage: 100%)
Gene name: RPL31
Sequence domains: Ribosomal protein L31e
Large ribosomal subunit protein eL32 Chain: e
Molecule details ›
Chain: e
Length: 135 amino acids
Theoretical weight: 15.9 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q6QAT0 (Residues: 1-135; Coverage: 100%)
Gene name: RPL32
Sequence domains: Ribosomal protein L32
Ribosomal protein eL33 Chain: f
Molecule details ›
Chain: f
Length: 110 amino acids
Theoretical weight: 12.56 KDa
Source organism: Sus scrofa
Large ribosomal subunit protein eL34 Chain: g
Molecule details ›
Chain: g
Length: 117 amino acids
Theoretical weight: 13.33 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q29223 (Residues: 1-117; Coverage: 100%)
Gene name: RPL34
Sequence domains: Ribosomal protein L34e
Large ribosomal subunit protein uL29 Chain: h
Molecule details ›
Chain: h
Length: 123 amino acids
Theoretical weight: 14.59 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q29361 (Residues: 1-123; Coverage: 100%)
Gene name: RPL35
Sequence domains: Ribosomal L29 protein
Ribosomal protein eL36 Chain: i
Molecule details ›
Chain: i
Length: 105 amino acids
Theoretical weight: 12.29 KDa
Source organism: Sus scrofa
Ribosomal protein eL37 Chain: j
Molecule details ›
Chain: j
Length: 86 amino acids
Theoretical weight: 10.1 KDa
Source organism: Sus scrofa
Large ribosomal subunit protein eL38 Chain: k
Molecule details ›
Chain: k
Length: 70 amino acids
Theoretical weight: 8.24 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1VLH7 (Residues: 1-70; Coverage: 100%)
Sequence domains: Ribosomal L38e protein family
Large ribosomal subunit protein eL39 Chain: l
Molecule details ›
Chain: l
Length: 51 amino acids
Theoretical weight: 6.43 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: K7GP63 (Residues: 1-51; Coverage: 100%)
Gene names: LOC100525679, LOC100623540, RPL39
Sequence domains: Ribosomal L39 protein
Ubiquitin-ribosomal protein eL40 fusion protein Chain: m
Molecule details ›
Chain: m
Length: 128 amino acids
Theoretical weight: 14.76 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P63053 (Residues: 1-128; Coverage: 100%)
Gene names: UBA52, UBCEP2
Sequence domains:
Ribosomal protein eL41 Chain: n
Molecule details ›
Chain: n
Length: 25 amino acids
Theoretical weight: 3.47 KDa
Source organism: Sus scrofa
Ribosomal protein eL42 Chain: o
Molecule details ›
Chain: o
Length: 106 amino acids
Theoretical weight: 12.48 KDa
Source organism: Sus scrofa
Ribosomal protein eL43 Chain: p
Molecule details ›
Chain: p
Length: 91 amino acids
Theoretical weight: 10.17 KDa
Source organism: Sus scrofa
Ribosomal protein eL28 Chain: r
Molecule details ›
Chain: r
Length: 125 amino acids
Theoretical weight: 14.3 KDa
Source organism: Sus scrofa
Ribosomal protein uL1 Chain: z
Molecule details ›
Chain: z
Length: 217 amino acids
Theoretical weight: 24.88 KDa
Source organism: Sus scrofa
Protein transport protein Sec61 subunit alpha isoform 1 Chain: 1
Molecule details ›
Chain: 1
Length: 393 amino acids
Theoretical weight: 43.5 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1TV07 (Residues: 25-466; Coverage: 83%)
Gene name: SEC61A1
Sequence domains:
Sec61 gamma subunit Chain: 2
Molecule details ›
Chain: 2
Length: 68 amino acids
Theoretical weight: 7.75 KDa
Source organism: Sus scrofa
Sec61 beta subunit Chain: 3
Molecule details ›
Chain: 3
Length: 36 amino acids
Theoretical weight: 3.08 KDa
Source organism: Sus scrofa
Small ribosomal subunit protein uS2 Chain: SA
Molecule details ›
Chain: SA
Length: 295 amino acids
Theoretical weight: 32.96 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q4GWZ2 (Residues: 1-295; Coverage: 100%)
Gene names: LAMR1, RPSA
Sequence domains:
Small ribosomal subunit protein eS1 Chain: SB
Molecule details ›
Chain: SB
Length: 264 amino acids
Theoretical weight: 29.93 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: B6V8C8 (Residues: 1-264; Coverage: 100%)
Gene name: RPS3A
Sequence domains: Ribosomal S3Ae family
Small ribosomal subunit protein uS5 Chain: SC
Molecule details ›
Chain: SC
Length: 218 amino acids
Theoretical weight: 24.09 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: I3LJ87 (Residues: 32-249; Coverage: 82%)
Gene name: RPS2
Sequence domains:
Small ribosomal subunit protein uS3 Chain: SD
Molecule details ›
Chain: SD
Length: 243 amino acids
Theoretical weight: 26.73 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q0Z8U2 (Residues: 1-243; Coverage: 100%)
Gene name: RPS3
Sequence domains:
40S ribosomal protein S4 Chain: SE
Molecule details ›
Chain: SE
Length: 263 amino acids
Theoretical weight: 29.65 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A287B771 (Residues: 1-263; Coverage: 100%)
Gene name: RPS4X
Sequence domains:
Small ribosomal subunit protein uS7 Chain: SF
Molecule details ›
Chain: SF
Length: 204 amino acids
Theoretical weight: 22.91 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F2Z5E6 (Residues: 1-204; Coverage: 100%)
Gene name: RPS5
Sequence domains: Ribosomal protein S7p/S5e
Ribosomal protein eS6 Chain: SG
Molecule details ›
Chain: SG
Length: 249 amino acids
Theoretical weight: 28.75 KDa
Source organism: Sus scrofa
40S ribosomal protein S7 Chain: SH
Molecule details ›
Chain: SH
Length: 194 amino acids
Theoretical weight: 22.17 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A287A9Y6 (Residues: 1-194; Coverage: 100%)
Gene name: RPS7
Sequence domains: Ribosomal protein S7e
Ribosomal protein eS8 Chain: SI
Molecule details ›
Chain: SI
Length: 208 amino acids
Theoretical weight: 24.26 KDa
Source organism: Sus scrofa
Ribosomal protein uS4 Chain: SJ
Molecule details ›
Chain: SJ
Length: 194 amino acids
Theoretical weight: 22.64 KDa
Source organism: Sus scrofa
Ribosomal protein eS10 Chain: SK
Molecule details ›
Chain: SK
Length: 165 amino acids
Theoretical weight: 18.97 KDa
Source organism: Sus scrofa
Ribosomal protein uS17 Chain: SL
Molecule details ›
Chain: SL
Length: 158 amino acids
Theoretical weight: 18.47 KDa
Source organism: Sus scrofa
Small ribosomal subunit protein eS12 Chain: SM
Molecule details ›
Chain: SM
Length: 124 amino acids
Theoretical weight: 13.78 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P46405 (Residues: 9-132; Coverage: 94%)
Gene name: RPS12
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Small ribosomal subunit protein uS15 Chain: SN
Molecule details ›
Chain: SN
Length: 151 amino acids
Theoretical weight: 17.26 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1TFR5 (Residues: 63-213; Coverage: 71%)
Gene name: RPS13
Sequence domains:
Ribosomal protein uS11 Chain: SO
Molecule details ›
Chain: SO
Length: 151 amino acids
Theoretical weight: 16.3 KDa
Source organism: Sus scrofa
Small ribosomal subunit protein uS19 Chain: SP
Molecule details ›
Chain: SP
Length: 145 amino acids
Theoretical weight: 17.08 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P62844 (Residues: 1-145; Coverage: 100%)
Gene names: RIG, RPS15
Sequence domains: Ribosomal protein S19
Small ribosomal subunit protein uS9 Chain: SQ
Molecule details ›
Chain: SQ
Length: 146 amino acids
Theoretical weight: 16.48 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q29201 (Residues: 1-146; Coverage: 100%)
Gene name: RPS16
Sequence domains: Ribosomal protein S9/S16
Small ribosomal subunit protein eS17 Chain: SR
Molecule details ›
Chain: SR
Length: 135 amino acids
Theoretical weight: 15.55 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q6QAP7 (Residues: 1-135; Coverage: 100%)
Gene name: RPS17
Sequence domains: Ribosomal S17
Small ribosomal subunit protein uS13 Chain: SS
Molecule details ›
Chain: SS
Length: 152 amino acids
Theoretical weight: 17.76 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P62272 (Residues: 1-152; Coverage: 100%)
Gene name: RPS18
Sequence domains: Ribosomal protein S13/S18
Small ribosomal subunit protein eS19 Chain: ST
Molecule details ›
Chain: ST
Length: 145 amino acids
Theoretical weight: 16.09 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1SDD8 (Residues: 106-250; Coverage: 58%)
Sequence domains: Ribosomal protein S19e
Small ribosomal subunit protein uS10 Chain: SU
Molecule details ›
Chain: SU
Length: 119 amino acids
Theoretical weight: 13.36 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A1XQU9 (Residues: 1-119; Coverage: 100%)
Gene name: RPS20
Sequence domains: Ribosomal protein S10p/S20e
Small ribosomal subunit protein eS21 Chain: SV
Molecule details ›
Chain: SV
Length: 83 amino acids
Theoretical weight: 9.12 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P63221 (Residues: 1-83; Coverage: 100%)
Gene name: RPS21
Sequence domains: Ribosomal protein S21e
Ribosomal protein uS8 Chain: SW
Molecule details ›
Chain: SW
Length: 130 amino acids
Theoretical weight: 14.87 KDa
Source organism: Sus scrofa
Small ribosomal subunit protein uS12 Chain: SX
Molecule details ›
Chain: SX
Length: 143 amino acids
Theoretical weight: 15.85 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q6SA96 (Residues: 1-143; Coverage: 100%)
Gene name: RPS23
Sequence domains: Ribosomal protein S12/S23
40S ribosomal protein S24 Chain: SY
Molecule details ›
Chain: SY
Length: 132 amino acids
Theoretical weight: 15.37 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1SJK8 (Residues: 1-132; Coverage: 100%)
Gene name: RPS24
Sequence domains: Ribosomal protein S24e
Ribosomal protein es25 Chain: SZ
Molecule details ›
Chain: SZ
Length: 125 amino acids
Theoretical weight: 13.78 KDa
Source organism: Sus scrofa
Small ribosomal subunit protein eS26 Chain: Sa
Molecule details ›
Chain: Sa
Length: 115 amino acids
Theoretical weight: 13.05 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P49171 (Residues: 1-115; Coverage: 100%)
Gene name: RPS26
Sequence domains: Ribosomal protein S26e
40S ribosomal protein S27 Chain: Sb
Molecule details ›
Chain: Sb
Length: 84 amino acids
Theoretical weight: 9.48 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1W2B6 (Residues: 1-84; Coverage: 100%)
Gene name: RPS27
Sequence domains: Ribosomal protein S27
Small ribosomal subunit protein eS28 Chain: Sc
Molecule details ›
Chain: Sc
Length: 69 amino acids
Theoretical weight: 7.86 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q6QAT1 (Residues: 1-69; Coverage: 100%)
Gene name: RPS28
Sequence domains: Ribosomal protein S28e
Small ribosomal subunit protein uS14 Chain: Sd
Molecule details ›
Chain: Sd
Length: 56 amino acids
Theoretical weight: 6.61 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q6QAP6 (Residues: 1-56; Coverage: 100%)
Gene name: RPS29
Sequence domains: Ribosomal protein S14p/S29e
Ribosomal protein eS30 Chain: Se
Molecule details ›
Chain: Se
Length: 133 amino acids
Theoretical weight: 14.41 KDa
Source organism: Sus scrofa
Ubiquitin-ribosomal protein eS31 fusion protein Chain: Sf
Molecule details ›
Chain: Sf
Length: 156 amino acids
Theoretical weight: 18 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1W6H9 (Residues: 49-204; Coverage: 77%)
Gene name: RPS27A
Sequence domains:
Small ribosomal subunit protein RACK1 Chain: Sg
Molecule details ›
Chain: Sg
Length: 317 amino acids
Theoretical weight: 35.12 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P63246 (Residues: 1-317; Coverage: 100%)
Gene names: GNB2L1, RACK1
Sequence domains: WD domain, G-beta repeat
28S ribosomal RNA Chain: 5
Molecule details ›
Chain: 5
Length: 3722 nucleotides
Theoretical weight: 1206.1 KDa
Sequence domains: Eukaryotic large subunit ribosomal RNA
5S ribosomal RNA Chain: 7
Molecule details ›
Chain: 7
Length: 120 nucleotides
Theoretical weight: 38.69 KDa
Sequence domains: 5S ribosomal RNA
5.8S ribosomal RNA Chain: 8
Molecule details ›
Chain: 8
Length: 156 nucleotides
Theoretical weight: 50.14 KDa
Sequence domains: 5.8S ribosomal RNA
18S Ribosomal RNA Chain: S2
Molecule details ›
Chain: S2
Length: 1742 nucleotides
Theoretical weight: 561.96 KDa
Sequence domains: Eukaryotic small subunit ribosomal RNA
Messenger RNA Chain: S4
Molecule details ›
Chain: S4
Length: 10 nucleotides
Theoretical weight: 3.04 KDa
A/P tRNA Chain: S5
Molecule details ›
Chain: S5
Length: 74 nucleotides
Theoretical weight: 23.87 KDa
Sequence domains: tRNA
P/E tRNA Chain: S6
Molecule details ›
Chain: S6
Length: 76 nucleotides
Theoretical weight: 24.48 KDa
Sequence domains: tRNA

Ligands and Environments

2 bound ligands:
Ligand MG 166 x MG
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.9Å
Relevant EMDB volumes: EMD-2644

Quick links

Citations

57 review citations

Mechanisms of integral membrane protein insertion and folding.
Cymer et al. (2015)
56 more

16 mentions without citation

Mechanistic insight into eukaryotic 60S ribosomal subunit biogenesis by cryo-electron microscopy.
Greber BJ. (2016)
15 more