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Glutamate dehydrogenase in complex with NADH and GTP, open conformation

Source organism: Bos taurus
Biochemical function: identical protein binding
Biological process: tricarboxylic acid metabolic process
Cellular component: endoplasmic reticulum

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EC 1.4.1.3: Glutamate dehydrogenase (NAD(P)(+))

Reaction catalysed:
L-glutamate + H(2)O + NAD(P)(+) = 2-oxoglutarate + NH(3) + NAD(P)H
Systematic name:
L-glutamate:NAD(P)(+) oxidoreductase (deaminating)
Alternative Name(s):
  • Glutamic dehydrogenase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00208
Domain description: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
Occurring in:
  1. Glutamate dehydrogenase 1, mitochondrial
The deposited structure of PDB entry 3jd3 contains 6 copies of Pfam domain PF00208 (Glutamate/Leucine/Phenylalanine/Valine dehydrogenase) in Glutamate dehydrogenase 1, mitochondrial. Showing 1 copy in chain A.

PF02812
Domain description: Glu/Leu/Phe/Val dehydrogenase, dimerisation domain
Occurring in:
  1. Glutamate dehydrogenase 1, mitochondrial
The deposited structure of PDB entry 3jd3 contains 6 copies of Pfam domain PF02812 (Glu/Leu/Phe/Val dehydrogenase, dimerisation domain) in Glutamate dehydrogenase 1, mitochondrial. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006095
Domain description: Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase
Occurring in:
  1. Glutamate dehydrogenase 1, mitochondrial
IPR006096
Domain description: Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, C-terminal
Occurring in:
  1. Glutamate dehydrogenase 1, mitochondrial
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. Glutamate dehydrogenase 1, mitochondrial
IPR033922
Domain description: NAD(P) binding domain of glutamate dehydrogenase
Occurring in:
  1. Glutamate dehydrogenase 1, mitochondrial
IPR033524
Domain description: Leu/Phe/Val dehydrogenases active site
Occurring in:
  1. Glutamate dehydrogenase 1, mitochondrial
IPR006097
Domain description: Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, dimerisation domain
Occurring in:
  1. Glutamate dehydrogenase 1, mitochondrial
IPR014362
Domain description: Glutamate dehydrogenase
Occurring in:
  1. Glutamate dehydrogenase 1, mitochondrial
IPR046346
Domain description: Aminoacid dehydrogenase-like, N-terminal domain superfamily
Occurring in:
  1. Glutamate dehydrogenase 1, mitochondrial

Structure domains

CATH CATH domains
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. Glutamate dehydrogenase 1, mitochondrial
The deposited structure of PDB entry 3jd3 contains 6 copies of CATH domain 3.40.50.720 (Rossmann fold) in Glutamate dehydrogenase 1, mitochondrial. Showing 1 copy in chain A.
3.40.50.10860
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Leucine Dehydrogenase, chain A, domain 1
Occurring in:
  1. Glutamate dehydrogenase 1, mitochondrial
The deposited structure of PDB entry 3jd3 contains 6 copies of CATH domain 3.40.50.10860 (Rossmann fold) in Glutamate dehydrogenase 1, mitochondrial. Showing 1 copy in chain A.
1.10.287.140
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Helix Hairpins
Homology: Helix Hairpins
Occurring in:
  1. Glutamate dehydrogenase 1, mitochondrial
The deposited structure of PDB entry 3jd3 contains 6 copies of CATH domain 1.10.287.140 (Helix Hairpins) in Glutamate dehydrogenase 1, mitochondrial. Showing 1 copy in chain A.

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