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3-deoxy-manno-octulosonate cytidylyltransferase from Yersinia pestis

Source organism: Yersinia pestis CO92
Biochemical function: nucleotidyltransferase activity
Biological process: CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process
Cellular component: cytosol

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EC 2.7.7.38: 3-deoxy-manno-octulosonate cytidylyltransferase

Reaction catalysed:
CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate
Systematic name:
CTP:3-deoxy-D-manno-octulosonate cytidylyltransferase
Alternative Name(s):
  • 2-keto-3-deoxyoctonate cytidylyltransferase
  • 3-deoxy-D-manno-octulosonate cytidylyltransferase
  • CMP-2-keto-3-deoxyoctulosonic acid synthetase
  • CMP-3-deoxy-D-manno-octulosonate diphosphorylase
  • CMP-3-deoxy-D-manno-octulosonate pyrophosphorylase
  • CMP-3-deoxy-D-manno-octulosonate synthetase
  • CMP-KDO synthetase
  • CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase
  • Cytidine monophospho-3-deoxy-D-manno-octulosonate pyrophosphorylase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF02348
Domain description: Cytidylyltransferase
Occurring in:
  1. 3-deoxy-manno-octulosonate cytidylyltransferase
The deposited structure of PDB entry 3jtj contains 1 copy of Pfam domain PF02348 (Cytidylyltransferase) in 3-deoxy-manno-octulosonate cytidylyltransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR004528
Domain description: 3-deoxy-D-manno-octulosonate cytidylyltransferase
Occurring in:
  1. 3-deoxy-manno-octulosonate cytidylyltransferase
IPR029044
Domain description: Nucleotide-diphospho-sugar transferases
Occurring in:
  1. 3-deoxy-manno-octulosonate cytidylyltransferase
IPR003329
Domain description: Acylneuraminate cytidylyltransferase
Occurring in:
  1. 3-deoxy-manno-octulosonate cytidylyltransferase

Structure domain

CATH CATH domain
3.90.550.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Homology: Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Occurring in:
  1. 3-deoxy-manno-octulosonate cytidylyltransferase
The deposited structure of PDB entry 3jtj contains 1 copy of CATH domain 3.90.550.10 (Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A) in 3-deoxy-manno-octulosonate cytidylyltransferase. Showing 1 copy in chain A.

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