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Crystal Structure Analysis of EndosialidaseNF at 0.98 A Resolution

Source organism: Escherichia phage K1F
Biochemical function: endo-alpha-(2,8)-sialidase activity
Biological process: not assigned
Cellular component: not assigned

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EC 3.2.1.129: Endo-alpha-sialidase

Reaction catalysed:
Endohydrolysis of (2->8)-alpha-sialosyl linkages in oligo- or poly(sialic) acids
Systematic name:
Polysialoside (2->8)-alpha-sialosylhydrolase
Alternative Name(s):
  • Alpha-2,8-sialosylhydrolase
  • Endo-N-acetylneuraminidase
  • Endo-N-acylneuraminidase
  • Endoneuraminidase
  • Endosialidase
  • Poly(alpha-2,8-sialoside) alpha-2,8-sialosylhydrolase
  • Poly(alpha-2,8-sialosyl) endo-N-acetylneuraminidase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF12219
Domain description: Catalytic domain of bacteriophage endosialidase
Occurring in:
  1. Mature tail spike protein
The deposited structure of PDB entry 3ju4 contains 1 copy of Pfam domain PF12219 (Catalytic domain of bacteriophage endosialidase) in Mature tail spike protein. Showing 1 copy in chain A.

PF12195
Domain description: Beta barrel domain of bacteriophage endosialidase
Occurring in:
  1. Mature tail spike protein
The deposited structure of PDB entry 3ju4 contains 1 copy of Pfam domain PF12195 (Beta barrel domain of bacteriophage endosialidase) in Mature tail spike protein. Showing 1 copy in chain A.

PF12217
Domain description: Catalytic beta propeller domain of bacteriophage endosialidase
Occurring in:
  1. Mature tail spike protein
The deposited structure of PDB entry 3ju4 contains 1 copy of Pfam domain PF12217 (Catalytic beta propeller domain of bacteriophage endosialidase) in Mature tail spike protein. Showing 1 copy in chain A.

PF12218
Domain description: N terminal extension of bacteriophage endosialidase
Occurring in:
  1. Mature tail spike protein
The deposited structure of PDB entry 3ju4 contains 1 copy of Pfam domain PF12218 (N terminal extension of bacteriophage endosialidase) in Mature tail spike protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001724
Domain description: Glycosyl hydrolase 58
Occurring in:
  1. Mature tail spike protein
IPR044914
Domain description: Endosialidase, C-terminal domain superfamily
Occurring in:
  1. Mature tail spike protein
IPR024430
Domain description: Endosialidase, C-terminal domain
Occurring in:
  1. Mature tail spike protein
IPR024427
Domain description: Endosialidase, beta barrel domain
Occurring in:
  1. Mature tail spike protein
IPR023366
Domain description: ATP synthase subunit alpha, N-terminal domain-like superfamily
Occurring in:
  1. Mature tail spike protein
IPR024428
Domain description: Endosialidase, beta propeller domain
Occurring in:
  1. Mature tail spike protein
IPR036278
Domain description: Sialidase superfamily
Occurring in:
  1. Mature tail spike protein
IPR024429
Domain description: Endosialidase, N-terminal extension domain
Occurring in:
  1. Mature tail spike protein

Structure domains

CATH CATH domains
2.120.10.10
Class: Mainly Beta
Architecture: 6 Propeller
Topology: Neuraminidase
Homology: Neuraminidase
Occurring in:
  1. Mature tail spike protein
The deposited structure of PDB entry 3ju4 contains 1 copy of CATH domain 2.120.10.10 (Neuraminidase) in Mature tail spike protein. Showing 1 copy in chain A.
4.10.1090.10
Class: Few Secondary Structures
Architecture: Irregular
Topology: Endosialidase, domain 4
Homology: Endosialidase, domain 4
Occurring in:
  1. Mature tail spike protein
The deposited structure of PDB entry 3ju4 contains 1 copy of CATH domain 4.10.1090.10 (Endosialidase, domain 4) in Mature tail spike protein. Showing 1 copy in chain A.
2.40.30.20
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Elongation Factor Tu (Ef-tu); domain 3
Homology: Elongation Factor Tu (Ef-tu); domain 3
Occurring in:
  1. Mature tail spike protein
The deposited structure of PDB entry 3ju4 contains 1 copy of CATH domain 2.40.30.20 (Elongation Factor Tu (Ef-tu); domain 3) in Mature tail spike protein. Showing 1 copy in chain A.
3.30.750.60
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Transcription Regulator spoIIAA
Homology: Endosialidase, N-terminal extension domain
Occurring in:
  1. Mature tail spike protein
The deposited structure of PDB entry 3ju4 contains 1 copy of CATH domain 3.30.750.60 (Transcription Regulator spoIIAA) in Mature tail spike protein. Showing 1 copy in chain A.

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