EC 5.2.1.8: Peptidylprolyl isomerase
Reaction catalysed:
Peptidylproline (omega=180) = peptidylproline (omega=0)
Systematic name:
Peptidylproline cis-trans-isomerase
Alternative Name(s):
- Cyclophilin
- PPIase
- Peptide bond isomerase
- Peptidyl-prolyl cis-trans isomerase
- Peptidylprolyl cis-trans isomerase
- Rotamase
GO terms
Biochemical function:
- heparan sulfate binding
- RNA polymerase II CTD heptapeptide repeat P6 isomerase activity
- RNA polymerase II CTD heptapeptide repeat P3 isomerase activity
- unfolded protein binding
- virion binding
- cyclosporin A binding
- protein binding
- integrin binding
- peptidyl-prolyl cis-trans isomerase activity
- RNA binding
Biological process:
- regulation of apoptotic signaling pathway
- negative regulation of viral life cycle
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
- platelet aggregation
- negative regulation of protein K48-linked ubiquitination
- cell adhesion molecule production
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of protein secretion
- positive regulation of viral genome replication
- regulation of viral genome replication
- positive regulation of MAPK cascade
- endothelial cell activation
- cellular response to oxidative stress
- lipid droplet organization
- negative regulation of stress-activated MAPK cascade
- activation of protein kinase B activity
- leukocyte chemotaxis
- neutrophil chemotaxis
- neuron differentiation
- platelet activation
- viral release from host cell
- apoptotic process
- negative regulation of protein kinase activity
- protein folding
- regulation of transcription by RNA polymerase II
- positive regulation of protein phosphorylation
- negative regulation of protein phosphorylation
- protein peptidyl-prolyl isomerization
Cellular component:
Sequence family
Protein family (Pfam)
InterPro annotations
IPR002130
Domain description:
Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
Occurring in:
Occurring in:
IPR020892
Domain description:
Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
Occurring in:
Occurring in:
CATH domain