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Crystal Structure of hPNMT in Complex AdoHcy and 2-Amino-1-methylbenzimidazole

Source organism: Homo sapiens
Biochemical function: transferase activity
Biological process: catecholamine biosynthetic process
Cellular component: cytosol

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EC 2.1.1.28: Phenylethanolamine N-methyltransferase

Reaction catalysed:
S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine
Systematic name:
S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase
Alternative Name(s):
  • Noradrenaline N-methyltransferase
  • Noradrenaline N-methyltransferase
  • Norepinephrine N-methyltransferase
  • Norepinephrine methyltransferase
  • Phenethanolamine N-methyltransferase
  • Phenethanolamine methyltransferase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01234
Domain description: NNMT/PNMT/TEMT family
Occurring in:
  1. Phenylethanolamine N-methyltransferase
The deposited structure of PDB entry 3kqt contains 2 copies of Pfam domain PF01234 (NNMT/PNMT/TEMT family) in Phenylethanolamine N-methyltransferase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR000940
Domain description: Methyltransferase, NNMT/PNMT/TEMT
Occurring in:
  1. Phenylethanolamine N-methyltransferase
IPR029063
Domain description: S-adenosyl-L-methionine-dependent methyltransferase superfamily
Occurring in:
  1. Phenylethanolamine N-methyltransferase
IPR025820
Domain description: Methyltransferase NNMT/PNMT/TEMT, conserved site
Occurring in:
  1. Phenylethanolamine N-methyltransferase

Structure domain

CATH CATH domain
3.40.50.150
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Vaccinia Virus protein VP39
Occurring in:
  1. Phenylethanolamine N-methyltransferase
The deposited structure of PDB entry 3kqt contains 2 copies of CATH domain 3.40.50.150 (Rossmann fold) in Phenylethanolamine N-methyltransferase. Showing 1 copy in chain B.

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