› 3kxv

X-ray diffraction
2Å resolution

Structure of complement Factor H variant Q1139A

Released:
DOI: 10.2210/pdb3kxv/pdb
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PDB entry 3kxv coloured by chain, front view.
PDB entry 3kxv coloured by chain, side view.
PDB entry 3kxv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Both domain 19 and domain 20 of factor H are involved in binding to complement C3b and C3d.
Bhattacharjee A, Lehtinen MJ, Kajander T, Goldman A, Jokiranta TS
Mol Immunol 47 1686-91 (2010)
PMID: 20378178

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140221 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement factor H Chain: A
Molecule details ›
Chain: A
Length: 133 amino acids
Theoretical weight: 15.04 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P08603 (Residues: 1103-1231; Coverage: 11%)
Gene names: CFH, HF, HF1, HF2
Sequence domains: Sushi repeat (SCR repeat)
Structure domains: Complement Module, domain 1

Ligands and Environments

1 bound ligand:
Ligand SO4 6 x SO4
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ESRF BEAMLINE ID14-3
Spacegroup: I4122
Unit cell:
a: 91.46Å b: 91.46Å c: 110.52Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.207 0.244
Expression system: Komagataella pastoris

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Citations

6 review citations

Complement System Part I - Molecular Mechanisms of Activation and Regulation.
Merle et al. (2015)
5 more

1 mention without citation

Structure of complement C6 suggests a mechanism for initiation and unidirectional, sequential assembly of membrane attack complex (MAC).
Aleshin et al. (2012)

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