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Complex structure of SidM/DrrA with the wild type Rab1

Source organisms:
Biochemical function: GTP binding
Biological process: not assigned
Cellular component: not assigned

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EC 3.6.5.2: Small monomeric GTPase

Reaction catalysed:
GTP + H(2)O = GDP + phosphate
Systematic name:
GTP phosphohydrolase (cell-regulating)

EC 2.7.7.n6: Guanine phosphate-protein transferase

Reaction catalysed:
GTP + [protein]-L-tyrosine = diphosphate + [protein]-O(4)-(5'-guanylyl)-L-tyrosine
Systematic name:
GTP:[protein] adenylyltransferase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00071
Domain description: Ras family
Occurring in:
  1. Ras-related protein Rab-1A
The deposited structure of PDB entry 3l0i contains 2 copies of Pfam domain PF00071 (Ras family) in Ras-related protein Rab-1A. Showing 1 copy in chain D.

PF20851
Domain description: SidM, Rab1-activation domain
Occurring in:
  1. Multifunctional virulence effector protein DrrA
The deposited structure of PDB entry 3l0i contains 2 copies of Pfam domain PF20851 (SidM, Rab1-activation domain) in Multifunctional virulence effector protein DrrA. Showing 1 copy in chain C.

PF20879
Domain description: SidM, N-terminal domain
Occurring in:
  1. Multifunctional virulence effector protein DrrA
The deposited structure of PDB entry 3l0i contains 2 copies of Pfam domain PF20879 (SidM, N-terminal domain) in Multifunctional virulence effector protein DrrA. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR001806
Domain description: Small GTPase
Occurring in:
  1. Ras-related protein Rab-1A
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Ras-related protein Rab-1A
IPR005225
Domain description: Small GTP-binding domain
Occurring in:
  1. Ras-related protein Rab-1A
IPR043519
Domain description: Nucleotidyltransferase superfamily
Occurring in:
  1. Ras-related protein Rab-1A
IPR033784
Domain description: SidM, Rab1-activation domain, Legionella pneumophila
Occurring in:
  1. Multifunctional virulence effector protein DrrA

Structure domains

CATH CATH domains
1.20.1440.370
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: de novo design (two linked rop proteins)
Homology: de novo design (two linked rop proteins)
Occurring in:
  1. Multifunctional virulence effector protein DrrA
The deposited structure of PDB entry 3l0i contains 2 copies of CATH domain 1.20.1440.370 (de novo design (two linked rop proteins)) in Multifunctional virulence effector protein DrrA. Showing 1 copy in chain C.
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Ras-related protein Rab-1A
The deposited structure of PDB entry 3l0i contains 2 copies of CATH domain 3.40.50.300 (Rossmann fold) in Ras-related protein Rab-1A. Showing 1 copy in chain D.
1.20.120.1520
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Four Helix Bundle (Hemerythrin (Met), subunit A)
Homology: Four Helix Bundle (Hemerythrin (Met), subunit A)
Occurring in:
  1. Multifunctional virulence effector protein DrrA
The deposited structure of PDB entry 3l0i contains 2 copies of CATH domain 1.20.120.1520 (Four Helix Bundle (Hemerythrin (Met), subunit A)) in Multifunctional virulence effector protein DrrA. Showing 1 copy in chain C.

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