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Human mesotrypsin complexed with amyloid precursor protein inhibitor(APPI)

Source organism: Homo sapiens
Biochemical function: serine-type endopeptidase inhibitor activity
Biological process: proteolysis
Cellular component: not assigned

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EC 3.4.21.4: Trypsin

Reaction catalysed:
Preferential cleavage: Arg-|-, Lys-|-.
Systematic name:
-
Alternative Name(s):
  • Alpha-trypsin
  • Beta-trypsin
  • Cocoonase
  • Parenzyme
  • Parenzymol
  • Pseudotrypsin
  • Sperm receptor hydrolase
  • Tripcellim
  • Tryptar
  • Tryptase
  • Trypure

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00014
Domain description: Kunitz/Bovine pancreatic trypsin inhibitor domain
Occurring in:
  1. Soluble APP-beta

PF00089
Domain description: Trypsin
Occurring in:
  1. Trypsin-3

InterPro InterPro annotations
IPR002223
Domain description: Pancreatic trypsin inhibitor Kunitz domain
Occurring in:
  1. Soluble APP-beta
IPR001314
Domain description: Peptidase S1A, chymotrypsin family
Occurring in:
  1. Trypsin-3
IPR001254
Domain description: Serine proteases, trypsin domain
Occurring in:
  1. Trypsin-3
IPR043504
Domain description: Peptidase S1, PA clan, chymotrypsin-like fold
Occurring in:
  1. Trypsin-3
IPR020901
Domain description: Proteinase inhibitor I2, Kunitz, conserved site
Occurring in:
  1. Soluble APP-beta
IPR036880
Domain description: Pancreatic trypsin inhibitor Kunitz domain superfamily
Occurring in:
  1. Soluble APP-beta
IPR018114
Domain description: Serine proteases, trypsin family, histidine active site
Occurring in:
  1. Trypsin-3
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. Trypsin-3

Structure domains

CATH CATH domains
2.40.10.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Thrombin, subunit H
Homology: Trypsin-like serine proteases
Occurring in:
  1. Trypsin-3
4.10.410.10
Class: Few Secondary Structures
Architecture: Irregular
Topology: Factor Xa Inhibitor
Homology: Pancreatic trypsin inhibitor Kunitz domain
Occurring in:
  1. Soluble APP-beta

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