› › Function and Biology

Structure of the Wall Teichoic Acid Polymerase TagF, H444N + CDPG (15 minute soak)

Source organism: Staphylococcus epidermidis RP62A
Biochemical function: CDP-glycerol glycerophosphotransferase activity
Biological process: cell wall organization
Cellular component: membrane

Quick links

EC 2.7.8.12: Teichoic acid poly(glycerol phosphate) polymerase

Reaction catalysed:
n CDP-glycerol + 4-O-((2R)-glycerophospho)-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = n CMP + 4-O-(((2R)-glycerophospho)n-(2R)-glycerophospho)-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
Systematic name:
CDP-glycerol:4-O-((2R)-glycerophospho)-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol glycerophosphotransferase
Alternative Name(s):
  • CDP-glycerol glycerophosphotransferase
  • CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase
  • CGPTase
  • Cytidine diphosphoglycerol glycerophosphotransferase
  • Glycerophosphate synthetase
  • Poly(glycerol phosphate) polymerase
  • Tag polymerase
  • TagF (gene name)
  • TarF (gene name)
  • Teichoic acid glycerol transferase
  • Teichoic-acid synthase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF04464
Domain description: CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
Occurring in:
  1. Teichoic acid poly(glycerol phosphate) polymerase
The deposited structure of PDB entry 3l7k contains 4 copies of Pfam domain PF04464 (CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase) in Teichoic acid poly(glycerol phosphate) polymerase. Showing 1 copy in chain C.

PF00535
Domain description: Glycosyl transferase family 2
Occurring in:
  1. Teichoic acid poly(glycerol phosphate) polymerase
The deposited structure of PDB entry 3l7k contains 4 copies of Pfam domain PF00535 (Glycosyl transferase family 2) in Teichoic acid poly(glycerol phosphate) polymerase. Showing 1 copy in chain C (this domain is out of the observed residue ranges!).

InterPro InterPro annotations
IPR029044
Domain description: Nucleotide-diphospho-sugar transferases
Occurring in:
  1. Teichoic acid poly(glycerol phosphate) polymerase
IPR043148
Domain description: CDP-glycerol glycerophosphotransferase, C-terminal domain
Occurring in:
  1. Teichoic acid poly(glycerol phosphate) polymerase
IPR007554
Domain description: CDP-glycerol glycerophosphotransferase
Occurring in:
  1. Teichoic acid poly(glycerol phosphate) polymerase
IPR043149
Domain description: CDP-glycerol glycerophosphotransferase, N-terminal domain
Occurring in:
  1. Teichoic acid poly(glycerol phosphate) polymerase
IPR001173
Domain description: Glycosyltransferase 2-like
Occurring in:
  1. Teichoic acid poly(glycerol phosphate) polymerase

Structure domains

CATH CATH domains
3.40.50.11820
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Teichoic acid poly(glycerol phosphate) polymerase
The deposited structure of PDB entry 3l7k contains 4 copies of CATH domain 3.40.50.11820 (Rossmann fold) in Teichoic acid poly(glycerol phosphate) polymerase. Showing 1 copy in chain C.
3.40.50.12580
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Teichoic acid poly(glycerol phosphate) polymerase
The deposited structure of PDB entry 3l7k contains 4 copies of CATH domain 3.40.50.12580 (Rossmann fold) in Teichoic acid poly(glycerol phosphate) polymerase. Showing 1 copy in chain C.

Quick links