› 3l8p

X-ray diffraction
2.4Å resolution

Crystal structure of cytoplasmic kinase domain of Tie2 complexed with inhibitor CEP11207

Released:
DOI: 10.2210/pdb3l8p/pdb
PDB entry 3l8p coloured by chain, front view.
PDB entry 3l8p coloured by chain, side view.
PDB entry 3l8p coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Fedorov AA, Fedorov EV, Pauletti D, Meyer SL, Hudkins RL, Almo SC

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169749 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Angiopoietin-1 receptor Chain: A
Molecule details ›
Chain: A
Length: 317 amino acids
Theoretical weight: 36.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02763 (Residues: 808-1124; Coverage: 29%)
Gene names: TEK, TIE2, VMCM, VMCM1
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 0CE 1 x 0CE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P42212
Unit cell:
a: 85.602Å b: 85.602Å c: 107.344Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.239 0.238 0.265
Expression system: Escherichia coli

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