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Crystal structure of the human Notch1 Negative Regulatory Region (NRR) bound to the fab fragment of an antagonist antibody

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: cell differentiation
Cellular component: membrane

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GO terms

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00066
Domain description: LNR domain
Occurring in:
  1. Notch 1 extracellular truncation
The deposited structure of PDB entry 3l95 contains 6 copies of Pfam domain PF00066 (LNR domain) in Notch 1 extracellular truncation. Showing 3 copies in chain C [auth X].

PF07684
Domain description: NOTCH protein
Occurring in:
  1. Notch 1 extracellular truncation
The deposited structure of PDB entry 3l95 contains 2 copies of Pfam domain PF07684 (NOTCH protein) in Notch 1 extracellular truncation. Showing 1 copy in chain C [auth X].

PF06816
Domain description: NOTCH protein
Occurring in:
  1. Notch 1 extracellular truncation
The deposited structure of PDB entry 3l95 contains 2 copies of Pfam domain PF06816 (NOTCH protein) in Notch 1 extracellular truncation. Showing 1 copy in chain C [auth X].

InterPro InterPro annotations
IPR000800
Domain description: Notch domain
Occurring in:
  1. Notch 1 extracellular truncation
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. anti-NRR1 fab fragment light chain
  2. anti-NRR1 fab fragment heavy chain
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. anti-NRR1 fab fragment light chain
  2. anti-NRR1 fab fragment heavy chain
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. anti-NRR1 fab fragment light chain
  2. anti-NRR1 fab fragment heavy chain
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. anti-NRR1 fab fragment light chain
  2. anti-NRR1 fab fragment heavy chain
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. anti-NRR1 fab fragment light chain
  2. anti-NRR1 fab fragment heavy chain
IPR035993
Domain description: Notch-like domain superfamily
Occurring in:
  1. Notch 1 extracellular truncation
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. anti-NRR1 fab fragment light chain
  2. anti-NRR1 fab fragment heavy chain
IPR011656
Domain description: Notch, NODP domain
Occurring in:
  1. Notch 1 extracellular truncation
IPR010660
Domain description: Notch, NOD domain
Occurring in:
  1. Notch 1 extracellular truncation
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. anti-NRR1 fab fragment light chain
  2. anti-NRR1 fab fragment heavy chain

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. anti-NRR1 fab fragment light chain
  2. anti-NRR1 fab fragment heavy chain
The deposited structure of PDB entry 3l95 contains 4 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in anti-NRR1 fab fragment light chain. Showing 2 copies in chain A.
The deposited structure of PDB entry 3l95 contains 4 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in anti-NRR1 fab fragment heavy chain. Showing 2 copies in chain B.
3.30.70.3310
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Alpha-Beta Plaits
Occurring in:
  1. Notch 1 extracellular truncation
The deposited structure of PDB entry 3l95 contains 2 copies of CATH domain 3.30.70.3310 (Alpha-Beta Plaits) in Notch 1 extracellular truncation. Showing 1 copy in chain C [auth X].
3.30.300.320
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: GMP Synthetase; Chain A, domain 3
Homology: GMP Synthetase; Chain A, domain 3
Occurring in:
  1. Notch 1 extracellular truncation
The deposited structure of PDB entry 3l95 contains 2 copies of CATH domain 3.30.300.320 (GMP Synthetase; Chain A, domain 3) in Notch 1 extracellular truncation. Showing 1 copy in chain C [auth X].

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