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Crystal structure of 3-oxoacyl-(acyl carrier protein) synthase III from Rhodopseudomonas palustris CGA009

Source organism: Rhodopseudomonas palustris CGA009
Biochemical function: acyltransferase activity
Biological process: secondary metabolite biosynthetic process
Cellular component: not assigned

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EC 2.3.1.41: Beta-ketoacyl-[acyl-carrier-protein] synthase I

Reaction catalysed:
Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein]
Systematic name:
Acyl-[acyl-carrier protein]:malonyl-[acyl-carrier protein] C-acyltransferase (decarboxylating)
Alternative Name(s):
  • 3-ketoacyl-acyl carrier protein synthase
  • 3-oxoacyl-[acyl-carrier-protein] synthase
  • 3-oxoacyl:ACP synthase I
  • Acyl-[acyl-carrier-protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating)
  • Acyl-malonyl acyl carrier protein-condensing enzyme
  • Acyl-malonyl(acyl-carrier-protein)-condensing enzyme
  • Beta-ketoacyl acyl carrier protein synthase
  • Beta-ketoacyl synthetase
  • Beta-ketoacyl-ACP synthase I
  • Beta-ketoacyl-ACP synthetase
  • Beta-ketoacyl-[acyl carrier protein] synthase
  • Beta-ketoacyl-acyl carrier protein synthetase
  • Beta-ketoacylsynthase
  • Condensing enzyme
  • FabB
  • FabF1
  • Fatty acid condensing enzyme
  • KAS I
  • KASI

GO terms

Sequence families

Pfam Protein families (Pfam)
PF08541
Domain description: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
Occurring in:
  1. Beta-ketoacyl-ACP synthase III
The deposited structure of PDB entry 3led contains 2 copies of Pfam domain PF08541 (3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal) in 3-oxoacyl-acyl carrier protein synthase III. Showing 1 copy in chain A.

PF08545
Domain description: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
Occurring in:
  1. Beta-ketoacyl-ACP synthase III
The deposited structure of PDB entry 3led contains 2 copies of Pfam domain PF08545 (3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III) in 3-oxoacyl-acyl carrier protein synthase III. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR016039
Domain description: Thiolase-like
Occurring in:
  1. Beta-ketoacyl-ACP synthase III
IPR013747
Domain description: Beta-ketoacyl-[acyl-carrier-protein] synthase III, C-terminal
Occurring in:
  1. Beta-ketoacyl-ACP synthase III
IPR013751
Domain description: Beta-ketoacyl-[acyl-carrier-protein] synthase III, N-terminal
Occurring in:
  1. Beta-ketoacyl-ACP synthase III
IPR029033
Domain description: Histidine phosphatase superfamily
Occurring in:
  1. Beta-ketoacyl-ACP synthase III

Structure domain

CATH CATH domain
3.40.47.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Peroxisomal Thiolase; Chain A, domain 1
Homology: Peroxisomal Thiolase; Chain A, domain 1
Occurring in:
  1. Beta-ketoacyl-ACP synthase III
The deposited structure of PDB entry 3led contains 4 copies of CATH domain 3.40.47.10 (Peroxisomal Thiolase; Chain A, domain 1) in 3-oxoacyl-acyl carrier protein synthase III. Showing 2 copies in chain A.

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