3leo

X-ray diffraction
2.1Å resolution

Structure of human Leukotriene C4 synthase mutant R31Q in complex with glutathione

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
homo dodecamer
homo trimer (preferred)
PDBe Complex ID:
PDB-CPX-172606 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leukotriene C4 synthase Chain: A
Molecule details ›
Chain: A
Length: 155 amino acids
Theoretical weight: 17.25 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q16873 (Residues: 2-150; Coverage: 99%)
Gene name: LTC4S
Sequence domains: MAPEG family
Structure domains: Membrane associated eicosanoid/glutathione metabolism-like domain

Ligands and Environments


Cofactor: Ligand GSH 1 x GSH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: F23
Unit cell:
a: 169.54Å b: 169.54Å c: 169.54Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.173 0.172 0.196
Expression system: Komagataella pastoris