› 3lfq

X-ray diffraction
2.03Å resolution

Crystal structure of CDK2 with SAR60, an aminoindazole type inhibitor

Released:
DOI: 10.2210/pdb3lfq/pdb
PDB entry 3lfq coloured by chain, front view.
PDB entry 3lfq coloured by chain, side view.
PDB entry 3lfq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2.
Lesuisse D, Dutruc-Rosset G, Tiraboschi G, Dreyer MK, Maignan S, Chevalier A, Halley F, Bertrand P, Burgevin MC, Quarteronet D, Rooney T
Bioorg Med Chem Lett 20 1985-9 (2010)
PMID: 20167481

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150313 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 298 amino acids
Theoretical weight: 33.98 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand A28 1 x A28
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P212121
Unit cell:
a: 54.22Å b: 72.74Å c: 72.01Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.187 0.241
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

Neuroglialpharmacology: myelination as a shared mechanism of action of psychotropic treatments.
Bartzokis G. (2012)
9 other articles

2 mentions without citation

The tumor suppressor CDKN3 controls mitosis.
Nalepa et al. (2013)
1 more