› 3lmy

X-ray diffraction
2.8Å resolution

The Crystal Structure of beta-hexosaminidase B in complex with Pyrimethamine

Released:
DOI: 10.2210/pdb3lmy/pdb
PDB entry 3lmy coloured by chain, front view.
PDB entry 3lmy coloured by chain, side view.
PDB entry 3lmy coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Bateman KS, Cherney MM, Withers SG, Mahuran DJ, Tropak M, James MNG

Function and Biology Details

Reaction catalysed: 
Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139695 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Beta-hexosaminidase subunit beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 556 amino acids
Theoretical weight: 63.18 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P07686 (Residues: 1-556; Coverage: 100%)
Gene names: HCC7, HEXB
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
4 bound ligands:
Ligand NDG 2 x NDG
Ligand NAG 3 x NAG
Ligand CP6 2 x CP6
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P6122
Unit cell:
a: 113.898Å b: 113.898Å c: 397.427Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.197 0.194 0.252

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