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Crystal structure of Thermolysin in complex with Xenon

Source organism: Bacillus thermoproteolyticus
Biochemical function: metalloendopeptidase activity
Biological process: proteolysis
Cellular component: not assigned

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EC 3.4.24.27: Thermolysin

Reaction catalysed:
Preferential cleavage: -|-Leu > -|-Phe.
Systematic name:
-
Alternative Name(s):
  • Bacillus thermoproteolyticus neutral proteinase
  • TLN
  • Thermoase
  • Thermoase Y10

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF02868
Domain description: Thermolysin metallopeptidase, alpha-helical domain
Occurring in:
  1. Thermolysin
The deposited structure of PDB entry 3ls7 contains 1 copy of Pfam domain PF02868 (Thermolysin metallopeptidase, alpha-helical domain) in Thermolysin. Showing 1 copy in chain A.

PF01447
Domain description: Thermolysin metallopeptidase, catalytic domain
Occurring in:
  1. Thermolysin
The deposited structure of PDB entry 3ls7 contains 1 copy of Pfam domain PF01447 (Thermolysin metallopeptidase, catalytic domain) in Thermolysin. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR023612
Domain description: Peptidase M4
Occurring in:
  1. Thermolysin
IPR027268
Domain description: Peptidase M4/M1, CTD superfamily
Occurring in:
  1. Thermolysin
IPR001570
Domain description: Peptidase M4, C-terminal
Occurring in:
  1. Thermolysin
IPR013856
Domain description: Peptidase M4 domain
Occurring in:
  1. Thermolysin

Structure domains

CATH CATH domains
1.10.390.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Neutral Protease; domain 2
Homology: Neutral Protease Domain 2
Occurring in:
  1. Thermolysin
The deposited structure of PDB entry 3ls7 contains 1 copy of CATH domain 1.10.390.10 (Neutral Protease; domain 2) in Thermolysin. Showing 1 copy in chain A.
3.10.170.10
Class: Alpha Beta
Architecture: Roll
Topology: Elastase; domain 1
Homology: Elastase; domain 1
Occurring in:
  1. Thermolysin
The deposited structure of PDB entry 3ls7 contains 1 copy of CATH domain 3.10.170.10 (Elastase; domain 1) in Thermolysin. Showing 1 copy in chain A.

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