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Crystal Structure of a Nelfinavir Resistant HIV-1 CRF01_AE Protease variant (N88S) in Complex with the Protease Inhibitor Darunavir.

X-ray diffraction
1.76Å resolution
PDB entry 3lzu coloured by chain, front view.
PDB entry 3lzu coloured by chain, side view.
PDB entry 3lzu coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Integrase
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Multimeric state: homo dimer
Accessible surface area: 9128.66 Å2
Buried surface area: 5504.03 Å2
Dissociation area: 2,120.45 Å2
Dissociation energy (ΔGdiss): 30.97 kcal/mol
Dissociation entropy (TΔSdiss): 11.43 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-150281

Macromolecules

Protease
Chains: A, B
Length: 99 amino acids
Theoretical weight: 10.74 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: P24740 (Residues: 482-580; Coverage: 7%)
Gene name: gag-pol
Pfam: Retroviral aspartyl protease
InterPro:
CATH: Acid Proteases
Protease in PDB entry 3lzu, assembly 1, front view.
Protease in PDB entry 3lzu, assembly 1, side view.
Protease in PDB entry 3lzu, assembly 1, top view.
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