› 3m3k

X-ray diffraction
1.79Å resolution

Ligand binding domain (S1S2) of GluA3 (flop)

Released:
DOI: 10.2210/pdb3m3k/pdb
PDB entry 3m3k coloured by chain, front view.
PDB entry 3m3k coloured by chain, side view.
PDB entry 3m3k coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Molecular mechanism of flop selectivity and subsite recognition for an AMPA receptor allosteric modulator: structures of GluA2 and GluA3 in complexes with PEPA.
Ahmed AH, Ptak CP, Oswald RE
Biochemistry 49 2843-50 (2010)
PMID: 20199107

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148616 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 3 Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 258 amino acids
Theoretical weight: 28.97 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19492 (Residues: 417-530, 658-799; Coverage: 30%)
Gene names: GluA3, Glur3, Gria3
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
Ligand GLU 3 x GLU
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Unit cell:
a: 46.028Å b: 110.329Å c: 161.192Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.201 0.24
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.
Hansen et al. (2021)
4 more

2 mentions without citation

The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation.
Holley et al. (2012)
1 more