› 3m6g

X-ray diffraction
2Å resolution

Crystal structure of actin in complex with lobophorolide

Released:
DOI: 10.2210/pdb3m6g/pdb
PDB entry 3m6g coloured by chain, front view.
PDB entry 3m6g coloured by chain, side view.
PDB entry 3m6g coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Two molecules of lobophorolide cooperate to stabilize an actin dimer using both their "ring" and "tail" region.
Blain JC, Mok YF, Kubanek J, Allingham JS
Chem Biol 17 802-7 (2010)
PMID: 20797609

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159302 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Actin, alpha skeletal muscle Chains: A, B
Molecule details ›
Chains: A, B
Length: 371 amino acids
Theoretical weight: 41.33 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P68135 (Residues: 3-373; Coverage: 98%)
Gene names: ACTA, ACTA1
Sequence domains: Actin
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand MG 2 x MG
Ligand ATP 2 x ATP
Ligand LO3 2 x LO3
Ligand CA 4 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P21
Unit cell:
a: 53.932Å b: 86.419Å c: 100.868Å
α: 90° β: 94.91° γ: 90°
R-values:
R R work R free
0.185 0.183 0.227

Quick links

Citations

9 review citations

Marine natural products.
Blunt et al. (2012)
8 more