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The structure of N-formimino-L-Glutamate Iminohydrolase from Pseudomonas aeruginosa complexed with N-formimino-L-Aspartate

Source organism: Pseudomonas aeruginosa
Biochemical function: formimidoylglutamate deiminase activity
Biological process: L-histidine catabolic process to glutamate and formate
Cellular component: cytosol

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EC 3.5.3.13: Formimidoylglutamate deiminase

Reaction catalysed:
N-formimidoyl-L-glutamate + H(2)O = N-formyl-L-glutamate + NH(3)
Systematic name:
N-formimidoyl-L-glutamate iminohydrolase
Alternative Name(s):
  • Formiminoglutamate deiminase
  • Formiminoglutamic iminohydrolase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF01979
Domain description: Amidohydrolase family
Occurring in:
  1. Formimidoylglutamate deiminase
The deposited structure of PDB entry 3mdw contains 4 copies of Pfam domain PF01979 (Amidohydrolase family) in Formimidoylglutamate deiminase. Showing 1 copy in chain A.

PF22429
Domain description: Amidohydrolase BAB2_0307-like, N-terminal domain
Occurring in:
  1. Formimidoylglutamate deiminase

InterPro InterPro annotations
IPR011059
Domain description: Metal-dependent hydrolase, composite domain superfamily
Occurring in:
  1. Formimidoylglutamate deiminase
IPR032466
Domain description: Metal-dependent hydrolase
Occurring in:
  1. Formimidoylglutamate deiminase
IPR006680
Domain description: Amidohydrolase-related
Occurring in:
  1. Formimidoylglutamate deiminase
IPR010252
Domain description: Formimidoylglutamate deiminase
Occurring in:
  1. Formimidoylglutamate deiminase

Structure domains

CATH CATH domains
3.20.20.140
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Metal-dependent hydrolases
Occurring in:
  1. Formimidoylglutamate deiminase
The deposited structure of PDB entry 3mdw contains 4 copies of CATH domain 3.20.20.140 (TIM Barrel) in Formimidoylglutamate deiminase. Showing 1 copy in chain A.
2.30.40.10
Class: Mainly Beta
Architecture: Roll
Topology: Urease, subunit C; domain 1
Homology: Urease, subunit C, domain 1
Occurring in:
  1. Formimidoylglutamate deiminase
The deposited structure of PDB entry 3mdw contains 4 copies of CATH domain 2.30.40.10 (Urease, subunit C; domain 1) in Formimidoylglutamate deiminase. Showing 1 copy in chain A.

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