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Crystal Structure of Mycobacterium Tuberculosis Proteasome with propetide and an T1A mutation at beta-subunit

Source organism: Mycobacterium tuberculosis
Biochemical function: hydrolase activity
Biological process: proteolysis involved in protein catabolic process
Cellular component: plasma membrane

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EC 3.4.25.1: Proteasome endopeptidase complex

Reaction catalysed:
Cleavage of peptide bonds with very broad specificity.
Alternative Name(s):
  • 26S protease
  • Alkaline protease
  • Ingensin
  • Large multicatalytic protease
  • Lens neutral proteinase
  • MCP
  • Macropain
  • Multicatalytic endopeptidase complex
  • Multicatalytic proteinase
  • Multicatalytic proteinase (complex)
  • Prosome
  • Proteasome
  • Proteasome organelle
  • Tricorn protease
  • Tricorn proteinase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00227
Domain description: Proteasome subunit
Occurring in:
  1. Proteasome subunit alpha
  2. Proteasome subunit beta
The deposited structure of PDB entry 3mka contains 14 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha. Showing 1 copy in chain M.
The deposited structure of PDB entry 3mka contains 14 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta. Showing 1 copy in chain J.

InterPro InterPro annotations
IPR029055
Domain description: Nucleophile aminohydrolases, N-terminal
Occurring in:
  1. Proteasome subunit alpha
  2. Proteasome subunit beta
IPR023333
Domain description: Proteasome B-type subunit
Occurring in:
  1. Proteasome subunit beta
IPR022483
Domain description: Proteasome subunit beta, actinobacteria
Occurring in:
  1. Proteasome subunit beta
IPR001353
Domain description: Proteasome, subunit alpha/beta
Occurring in:
  1. Proteasome subunit alpha
  2. Proteasome subunit beta
IPR022296
Domain description: Proteasome, alpha subunit, bacterial
Occurring in:
  1. Proteasome subunit alpha
IPR023332
Domain description: Proteasome alpha-type subunit
Occurring in:
  1. Proteasome subunit alpha

Structure domain

CATH CATH domain
3.60.20.10
Class: Alpha Beta
Architecture: 4-Layer Sandwich
Topology: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homology: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Occurring in:
  1. Proteasome subunit alpha
  2. Proteasome subunit beta
The deposited structure of PDB entry 3mka contains 14 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Proteasome subunit alpha. Showing 1 copy in chain M.
The deposited structure of PDB entry 3mka contains 14 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Proteasome subunit beta. Showing 1 copy in chain J.

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