› 3mqi

X-ray diffraction
2.3Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193729 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcription factor COE1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 96 amino acids
Theoretical weight: 10.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UH73 (Residues: 258-351; Coverage: 16%)
Gene names: COE1, EBF, EBF1
Sequence domains: IPT/TIG domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand EMC 6 x EMC
Ligand TMO 1 x TMO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: C2
Unit cell:
a: 86.291Å b: 57.073Å c: 69.14Å
α: 90° β: 93.17° γ: 90°
R-values:
R R work R free
0.235 0.233 0.273
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

The regulatory network of B-cell differentiation: a focused view of early B-cell factor 1 function.
Boller et al. (2014)
2 more

5 mentions without citation

Comprehensive characterization of protein-protein interactions perturbed by disease mutations.
Cheng et al. (2021)
4 more