› › Function and Biology

APPEP_PEPCLOSE+PP closed state

Source organism: Aeromonas caviae
Biochemical function: oligopeptidase activity
Biological process: proteolysis
Cellular component: cytosol

Quick links

EC 3.4.21.26: Prolyl oligopeptidase

Reaction catalysed:
Hydrolysis of --Pro-|- and to a lesser extent --Ala-|- in oligopeptides.
Systematic name:
-
Alternative Name(s):
  • Endoprolylpeptidase
  • Post-proline cleaving enzyme
  • Post-proline endopeptidase
  • Proline endopeptidase
  • Proline-specific endopeptidase
  • Prolyl endopeptidase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00326
Domain description: Prolyl oligopeptidase family
Occurring in:
  1. prolyl oligopeptidase
The deposited structure of PDB entry 3muo contains 1 copy of Pfam domain PF00326 (Prolyl oligopeptidase family) in Prolyl endopeptidase. Showing 1 copy in chain A.

PF02897
Domain description: Prolyl oligopeptidase, N-terminal beta-propeller domain
Occurring in:
  1. prolyl oligopeptidase
The deposited structure of PDB entry 3muo contains 1 copy of Pfam domain PF02897 (Prolyl oligopeptidase, N-terminal beta-propeller domain) in Prolyl endopeptidase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002470
Domain description: Peptidase S9A, prolyl oligopeptidase
Occurring in:
  1. prolyl oligopeptidase
IPR029058
Domain description: Alpha/Beta hydrolase fold
Occurring in:
  1. prolyl oligopeptidase
IPR002471
Domain description: Peptidase S9, serine active site
Occurring in:
  1. prolyl oligopeptidase
IPR001375
Domain description: Peptidase S9, prolyl oligopeptidase, catalytic domain
Occurring in:
  1. prolyl oligopeptidase
IPR023302
Domain description: Peptidase S9A, N-terminal domain
Occurring in:
  1. prolyl oligopeptidase

Structure domains

CATH CATH domains
3.40.50.1820
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: alpha/beta hydrolase
Occurring in:
  1. prolyl oligopeptidase
The deposited structure of PDB entry 3muo contains 1 copy of CATH domain 3.40.50.1820 (Rossmann fold) in Prolyl endopeptidase. Showing 1 copy in chain A.
2.130.10.120
Class: Mainly Beta
Architecture: 7 Propeller
Topology: Methylamine Dehydrogenase; Chain H
Homology: Prolyl oligopeptidase, N-terminal domain
Occurring in:
  1. prolyl oligopeptidase
The deposited structure of PDB entry 3muo contains 1 copy of CATH domain 2.130.10.120 (Methylamine Dehydrogenase; Chain H) in Prolyl endopeptidase. Showing 1 copy in chain A.

Quick links