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Crystal structure of a human prolactin receptor antagonist in complex with the extracellular domain of the human prolactin receptor

Source organism: Homo sapiens
Biochemical function: cytokine receptor activity
Biological process: positive regulation of lactation
Cellular component: membrane

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF09067
Domain description: Erythropoietin receptor, ligand binding
Occurring in:
  1. Prolactin receptor
The deposited structure of PDB entry 3mzg contains 1 copy of Pfam domain PF09067 (Erythropoietin receptor, ligand binding) in Prolactin receptor. Showing 1 copy in chain B.

PF00103
Domain description: Somatotropin hormone family
Occurring in:
  1. Prolactin
The deposited structure of PDB entry 3mzg contains 1 copy of Pfam domain PF00103 (Somatotropin hormone family) in Prolactin. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001400
Domain description: Somatotropin/prolactin
Occurring in:
  1. Prolactin
IPR003961
Domain description: Fibronectin type III
Occurring in:
  1. Prolactin receptor
IPR036116
Domain description: Fibronectin type III superfamily
Occurring in:
  1. Prolactin receptor
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Prolactin receptor
IPR018116
Domain description: Somatotropin hormone, conserved site
Occurring in:
  1. Prolactin
IPR009079
Domain description: Four-helical cytokine-like, core
Occurring in:
  1. Prolactin
IPR003528
Domain description: Long hematopoietin receptor, single chain, conserved site
Occurring in:
  1. Prolactin receptor
IPR015152
Domain description: Growth hormone/erythropoietin receptor, ligand binding
Occurring in:
  1. Prolactin receptor

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Prolactin receptor
The deposited structure of PDB entry 3mzg contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Prolactin receptor. Showing 2 copies in chain B.
1.20.1250.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Growth Hormone; Chain: A;
Homology: Growth Hormone; Chain: A;
Occurring in:
  1. Prolactin
The deposited structure of PDB entry 3mzg contains 1 copy of CATH domain 1.20.1250.10 (Growth Hormone; Chain: A;) in Prolactin. Showing 1 copy in chain A.

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