Function and Biology Details
Reaction catalysed:
ATP + propanoyl-CoA + HCO(3)(-) = ADP + phosphate + (S)-methylmalonyl-CoA
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
- ClpP/crotonase-like domain superfamily
- Biotin/lipoyl attachment
- Acetyl-coenzyme A carboxyltransferase, C-terminal
- Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
- Acetyl-coenzyme A carboxyltransferase, N-terminal
- Metallo-dependent phosphatase-like
- Biotin-binding site
8 more domains
Structure analysis Details
Assembly composition:
hetero dodecamer (preferred)
Assembly name:
Propionyl-CoA carboxylase (preferred)
PDBe Complex ID:
PDB-CPX-557032 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Propionyl-CoA carboxylase alpha chain
Molecule details ›
Chains: A, C, E, G, I, K
Length: 681 amino acids
Theoretical weight: 73.95 KDa
Source organism: Ruegeria pomeroyi
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 681 amino acids
Theoretical weight: 73.95 KDa
Source organism: Ruegeria pomeroyi
Expression system: Escherichia coli
UniProt:
- Canonical:
Q5LUF3 (Residues: 1-681; Coverage: 100%)
Sequence domains:
- Biotin carboxylase, N-terminal domain
- Carbamoyl-phosphate synthase L chain, ATP binding domain
- Biotin carboxylase C-terminal domain
- Propionyl-coenzyme A carboxylase BT domain
- Biotin-requiring enzyme
Propionyl-CoA carboxylase beta chain
Molecule details ›
Chains: B, D, F, H, J, L
Length: 531 amino acids
Theoretical weight: 58.47 KDa
Source organism: Roseobacter denitrificans OCh 114
Expression system: Escherichia coli
UniProt:
Sequence domains: Carboxyl transferase domain
Structure domains: 2-enoyl-CoA Hydratase; Chain A, domain 1
Length: 531 amino acids
Theoretical weight: 58.47 KDa
Source organism: Roseobacter denitrificans OCh 114
Expression system: Escherichia coli
UniProt:
- Canonical: Q168G2 (Residues: 1-510; Coverage: 100%)
Sequence domains: Carboxyl transferase domain
Structure domains: 2-enoyl-CoA Hydratase; Chain A, domain 1
