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Structural characterization for the nucleotide binding ability of subunit A of the A1AO ATP synthase

Source organism: Pyrococcus horikoshii
Biochemical function: proton-transporting ATPase activity, rotational mechanism
Biological process: proton transmembrane transport
Cellular component: proton-transporting two-sector ATPase complex, catalytic domain

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EC 7.1.2.2: H(+)-transporting two-sector ATPase

Reaction catalysed:
ATP + H(2)O + 4 H(+)(Side 1) = ADP + phosphate + 4 H(+)(Side 2)
Systematic name:
ATP phosphohydrolase (two-sector, H(+)-transporting)
Alternative Name(s):
  • ATP synthase
  • Bacterial Ca(2+)/Mg(2+) ATPase
  • Chloroplast ATPase
  • Coupling factors (F(o), F(1) and CF(1))
  • F(0)F(1)-ATPase
  • F(1)-ATPase
  • F(o)F(1)-ATPase
  • H(+)-transporting ATP synthase
  • H(+)-transporting ATPase
  • Mitochondrial ATPase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF22919
Domain description: C-terminal domain of V and A type ATP synthase
Occurring in:
  1. Endonuclease PI-Pho2

PF00006
Domain description: ATP synthase alpha/beta family, nucleotide-binding domain
Occurring in:
  1. Endonuclease PI-Pho2
The deposited structure of PDB entry 3nd8 contains 1 copy of Pfam domain PF00006 (ATP synthase alpha/beta family, nucleotide-binding domain) in Endonuclease PI-Pho2. Showing 1 copy in chain A.

PF16886
Domain description: ATPsynthase alpha/beta subunit N-term extension
Occurring in:
  1. Endonuclease PI-Pho2
The deposited structure of PDB entry 3nd8 contains 1 copy of Pfam domain PF16886 (ATPsynthase alpha/beta subunit N-term extension) in Endonuclease PI-Pho2. Showing 1 copy in chain A.

PF02874
Domain description: ATP synthase alpha/beta family, beta-barrel domain
Occurring in:
  1. Endonuclease PI-Pho2
The deposited structure of PDB entry 3nd8 contains 1 copy of Pfam domain PF02874 (ATP synthase alpha/beta family, beta-barrel domain) in Endonuclease PI-Pho2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Endonuclease PI-Pho2
IPR022878
Domain description: V-type ATP synthase catalytic alpha chain
Occurring in:
  1. Endonuclease PI-Pho2
IPR024034
Domain description: ATPase, F1/V1 complex, beta/alpha subunit, C-terminal
Occurring in:
  1. Endonuclease PI-Pho2
IPR020003
Domain description: ATPase, alpha/beta subunit, nucleotide-binding domain, active site
Occurring in:
  1. Endonuclease PI-Pho2
IPR000194
Domain description: ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain
Occurring in:
  1. Endonuclease PI-Pho2
IPR031686
Domain description: ATPsynthase alpha/beta subunit, N-terminal extension
Occurring in:
  1. Endonuclease PI-Pho2
IPR004100
Domain description: ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain
Occurring in:
  1. Endonuclease PI-Pho2
IPR036121
Domain description: ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily
Occurring in:
  1. Endonuclease PI-Pho2
IPR005726
Domain description: ATP synthase alpha chain, archaea
Occurring in:
  1. Endonuclease PI-Pho2
IPR023366
Domain description: ATP synthase subunit alpha, N-terminal domain-like superfamily
Occurring in:
  1. Endonuclease PI-Pho2

Structure domains

CATH CATH domains
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Endonuclease PI-Pho2
The deposited structure of PDB entry 3nd8 contains 1 copy of CATH domain 3.40.50.300 (Rossmann fold) in Endonuclease PI-Pho2. Showing 1 copy in chain A.
1.10.1140.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Bovine Mitochondrial F1-ATPase, ATP Synthase Beta Chain; Chain D, domain3
Homology: Bovine Mitochondrial F1-atpase; Atp Synthase Beta Chain; Chain D, domain 3
Occurring in:
  1. Endonuclease PI-Pho2
The deposited structure of PDB entry 3nd8 contains 1 copy of CATH domain 1.10.1140.10 (Bovine Mitochondrial F1-ATPase, ATP Synthase Beta Chain; Chain D, domain3) in Endonuclease PI-Pho2. Showing 1 copy in chain A.
2.40.50.100
Class: Mainly Beta
Architecture: Beta Barrel
Topology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Occurring in:
  1. Endonuclease PI-Pho2
The deposited structure of PDB entry 3nd8 contains 1 copy of CATH domain 2.40.50.100 (OB fold (Dihydrolipoamide Acetyltransferase, E2P)) in Endonuclease PI-Pho2. Showing 1 copy in chain A.

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