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Crystal structure of C-terminal domain of precorrin-6Y C5,15-methyltransferase from Rhodobacter capsulatus

Source organism: Rhodobacter capsulatus SB 1003
Biochemical function: protein methyltransferase activity
Biological process: cobalamin biosynthetic process
Cellular component: not assigned

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EC 2.1.1.132: Precorrin-6B C(5,15)-methyltransferase (decarboxylating)

Reaction catalysed:
(1a) S-adenosyl-L-methionine + precorrin-6B = S-adenosyl-L-homocysteine + precorrin-7 + CO(2)
Systematic name:
S-adenosyl-L-methionine:1-precorrin-6B C(5,15)-methyltransferase (C-12-decarboxylating)
Alternative Name(s):
  • CobL (gene name)
  • Precorrin-6 methyltransferase
  • Precorrin-6Y C(5,15)-methyltransferase (decarboxylating)
  • Precorrin-6Y methylase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

InterPro InterPro annotations
IPR029063
Domain description: S-adenosyl-L-methionine-dependent methyltransferase superfamily
Occurring in:
  1. Tetrapyrrole methylase domain-containing protein
IPR014008
Domain description: Cobalamin biosynthesis, precorrin-6Y methyltransferase, CbiT subunit
Occurring in:
  1. Tetrapyrrole methylase domain-containing protein
IPR014729
Domain description: Rossmann-like alpha/beta/alpha sandwich fold
Occurring in:
  1. Tetrapyrrole methylase domain-containing protein

Structure domain

CATH CATH domain
3.40.50.150
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Vaccinia Virus protein VP39
Occurring in:
  1. Tetrapyrrole methylase domain-containing protein
The deposited structure of PDB entry 3njr contains 2 copies of CATH domain 3.40.50.150 (Rossmann fold) in Tetrapyrrole methylase domain-containing protein. Showing 1 copy in chain A.

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